https://scholars.lib.ntu.edu.tw/handle/123456789/434704
標題: | Visible red light enhances physiological anagen entry in vivo and has direct and indirect stimulative effects in vitro | 作者: | YI-SHUAN SHEEN Fan, Sabrina Mai-Yi CHIH-CHIEH CHAN Wu, Yueh-Feng Jee, Shiou-Hwa SUNG-JAN LIN |
公開日期: | 2015 | 出版社: | John Wiley and Sons Inc. | 卷: | 47 | 期: | 1 | 起(迄)頁: | 50-59 | 來源出版物: | Lasers in Surgery and Medicine | 摘要: | Background and Objectives: Hair follicles are located at the interface of the external and internal environments and their cycling has been shown to be regulated by intra- and extra-follicular factors. The aim of this study is to examine whether or how hair follicles respond to visible light. Study Design/Materials and Methods: We examined the effect of 3 mW red (630 nm, 1 J/cm2), 2 mW green (522 nm, 1 J/cm2), and 2 mW blue light (463 nm, 1 J/cm2) on telogen in mice for 3 weeks. The photobiologic effects of red light on cell proliferation of outer root sheath keratinocytes and dermal papilla cells were studied in vitro. Results: We found that red light accelerated anagen entry faster than green and blue light in mice. Red light irradiation stimulated the proliferation of both outer root sheath keratinocytes and dermal papilla cells in a dose-dependent manner by promoting cell cycle progression. This stimulative effect was mediated via extracellular signal-regulated kinase phosphorylation in both cells. In a co-culture condition, dermal papilla cells irradiated by red light further enhanced keratinocyte proliferation, suggesting enhanced epithelial-mesenchymal interaction. In search for factors that mediated this paracrine effect, we found fibroblast growth factor 7 was upregulated in both mRNA and protein levels. The stimulative paracrine effect on keratinocytes was significantly inhibited by neutralizing antibody against fibroblast growth factor 7. Conclusions: These results suggest that hair follicles respond to visible light in vivo. Red light may promote physiological telogen to anagen transition by directly stimulating outer root sheath keratinocytes and indirectly by enhancing epithelial-mesenchymal interaction in vitro. © 2014 Wiley Periodicals, Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84921535568&doi=10.1002%2flsm.22316&partnerID=40&md5=b9567c1c9f66ae383cd1cca0c0e22c01 https://scholars.lib.ntu.edu.tw/handle/123456789/434704 |
ISSN: | 0196-8092 | DOI: | 10.1002/lsm.22316 |
顯示於: | 醫學系 |
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