https://scholars.lib.ntu.edu.tw/handle/123456789/434907
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | YUNG-TSU CHO | en_US |
dc.contributor.author | Lin, Jheng-Wei | en_US |
dc.contributor.author | Chen, Yi-Chun | en_US |
dc.contributor.author | Chang, Chia-Ying | en_US |
dc.contributor.author | Hsiao, Cheng-Hsiang | en_US |
dc.contributor.author | Chung, Wen-Hung | en_US |
dc.contributor.author | CHIA-YU CHU | en_US |
dc.creator | Cho Y.-T.;Lin J.-W.;Chen Y.-C.;Chang C.-Y.;Hsiao C.-H.;Chung W.-H.;Chia-Yu Chu | - |
dc.date.accessioned | 2019-12-04T08:43:42Z | - |
dc.date.available | 2019-12-04T08:43:42Z | - |
dc.date.issued | 2014-03 | - |
dc.identifier.issn | 0190-9622 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84894057183&doi=10.1016%2fj.jaad.2013.11.015&partnerID=40&md5=4ac8a21b05c89910ab5482c60bc605cb | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/434907 | - |
dc.description.abstract | Background Generalized bullous fixed drug eruption (GBFDE), a particular form of fixed drug eruption (FDE), is characterized by widespread blisters and erosions and can be confused with Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Objective We sought to analyze specific features of GBFDE and differentiate it from SJS/TEN. Methods We retrospectively studied patients with GBFDE and SJS/TEN during a period of 10 years. GBFDE was defined as typical FDE lesions with blisters involving at least 10% body surface area on at least 3 of 6 different anatomic sites. Clinical presentations; histopathological features; immunohistochemical patterns of cluster-of- differentiation (CD)3, CD4, CD8, CD56, Fas, Fas ligand, granzyme B, perforin, granulysin, and forkhead box P3 (Foxp3); and serum granulysin levels were compared. Results Twenty-three cases of GBFDE were collected. Patients with GBFDE had shorter latent periods, less mucosal involvement, more eosinophil infiltration, and dermal melanophages. Lesional infiltrates in GBFDE had more dermal CD4+ cells including Foxp3+ regulatory T cells, fewer intraepidermal CD56+ cells, and fewer intraepidermal granulysin+ cells. The serum level of granulysin in GBFDE was also significantly lower than in SJS/TEN. Limitations The number of cases in this study is small. Conclusion GBFDE is a distinct disease distinguishable from SJS/TEN by particular features such as granulysin, CD56, and Foxp3 expressions. ? 2013 by the American Academy of Dermatology, Inc. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Journal of the American Academy of Dermatology | en_US |
dc.subject | fixed drug eruption | en_US |
dc.subject | generalized bullous fixed drug eruption | en_US |
dc.subject | granulysin | en_US |
dc.subject | regulatory T cells | en_US |
dc.subject | Stevens-Johnson syndrome | en_US |
dc.subject | toxic epidermal necrolysis | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | fixed drug eruption; generalized bullous fixed drug eruption; granulysin; regulatory T cells; Stevens-Johnson syndrome; toxic epidermal necrolysis; Aged; Aged, 80 and over; Antigens, Differentiation, T-Lymphocyte; Biological Markers; Biopsy, Needle; Cohort Studies; Diagnosis, Differential; Drug Eruptions; Female; Forkhead Transcription Factors; Humans; Immunohistochemistry; Male; Middle Aged; Perforin; Prognosis; Retrospective Studies; Severity of Illness Index; Skin Diseases, Vesiculobullous; Stevens-Johnson Syndrome; Young Adult | - |
dc.title | Generalized bullous fixed drug eruption is distinct from Stevens-Johnson syndrome/toxic epidermal necrolysis by immunohistopathological features | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.jaad.2013.11.015 | - |
dc.identifier.pmid | 24388722 | - |
dc.identifier.scopus | 2-s2.0-84894057183 | - |
dc.relation.pages | 539 | en_US |
dc.relation.journalvolume | 70 | en_US |
dc.relation.journalissue | 3 | en_US |
dc.relation.pageend | 548 | en_US |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Dermatology-NTUH | - |
crisitem.author.dept | Dermatology | - |
crisitem.author.dept | Dermatology | - |
crisitem.author.dept | Dermatology-NTUH | - |
crisitem.author.orcid | 0000-0002-5297-8997 | - |
crisitem.author.orcid | 0000-0002-9370-3279 | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。