https://scholars.lib.ntu.edu.tw/handle/123456789/435009
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | TSEN-FANG TSAI | en_US |
dc.contributor.author | CHUNG-YI HU | en_US |
dc.contributor.author | Tsai, Wei-Ling | en_US |
dc.contributor.author | SUNG-JAN LIN | en_US |
dc.contributor.author | Liaw, Shwu-Huey | en_US |
dc.contributor.author | BOR-LUEN CHIANG | en_US |
dc.contributor.author | Lin, Pei-Jung | en_US |
dc.contributor.author | SHIOU-HWA JEE | en_US |
dc.contributor.author | CHIA-YU CHU | en_US |
dc.creator | Tsai T.-F.;Hu C.-Y.;Tsai W.-L.;Chia-Yu Chu;Lin S.-J.;Liaw S.-H.;Chiang B.-L.;Lin P.-J.;Jee S.-H. | - |
dc.date.accessioned | 2019-12-04T08:44:22Z | - |
dc.date.available | 2019-12-04T08:44:22Z | - |
dc.date.issued | 2002 | - |
dc.identifier.issn | 0340-3696 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0036020329&doi=10.1007%2fs00403-002-0324-0&partnerID=40&md5=ad1e999d14fd81d2aaa89d0dba751bb7 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/435009 | - |
dc.description.abstract | Previous serotyping in Chinese patients has failed to confirm an association between HLA-Cw6 and psoriasis. As serotyping has proved to be less valuable in the determination of HLA-C, genotyping of HLA-C in 68 Taiwanese psoriasis vulgaris (PSV) patients was performed using polymerase chain reaction/sequence-specific oligonucleotide probe hybridization (PCR-SSOPH) of HLA-Cw genes. Compared to 213 non-PSV control subjects, HLA-Cw6 was significantly associated with PSV (16.18% of PSV patients vs 5.16% of controls; odds ratio 3.53, Pc?10-4). The amino acid residues on the heavy chain of the HLA-Cw antigens from exon one to exon five were also analyzed. Asp 9, Ser 24, Ala 73, Asp 90, Trp 97, Trp 156 and Asn 77/Lys 80 were found to be positively associated with PSV (Pc?0.0044, 0.0008, 0.0026, 0.0014, 0.039, 0.0020 and 0.0000, respectively). | en_US |
dc.language.iso | en | en_US |
dc.publisher | Springer Verlag | en_US |
dc.relation.ispartof | Archives of Dermatological Research | en_US |
dc.subject | Chinese; HLA-Cw; Polymerase chain reaction/sequence-specific oligonucleotide probe hybridization (PCR-SSOPH); Psoriasis vulgaris; Taiwan | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | alanine; amino acid; asparagine; aspartic acid; HLA antigen; lysine; tryptophan; DNA; HLA C antigen; HLA Cw6; HLA DR antigen; HLA-Cw6; HLA-DRB1 antigen; adolescent; adult; aged; antigen specificity; article; Chinese; controlled study; disease association; exon; female; gene sequence; genetic analysis; genetic polymorphism; genetic susceptibility; genotype; human; hybridization; major clinical study; male; oligonucleotide probe; polymerase chain reaction; priority journal; protein analysis; protein determination; psoriasis; psoriasis vulgaris; risk; school child; serotyping; Taiwan; Asian; case control study; child; gene linkage disequilibrium; genetic polymorphism; genetics; immunology; middle aged; nucleotide sequence; Adolescent; Adult; Aged; Asian Continental Ancestry Group; Base Sequence; Case-Control Studies; Child; DNA; Female; HLA-C Antigens; HLA-DR Antigens; Humans; Linkage Disequilibrium; Male; Middle Aged; Polymorphism, Genetic; Psoriasis; Taiwan | - |
dc.title | HLA-Cw6 specificity and polymorphic residues are associated with susceptibility among Chinese psoriatics in Taiwan | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1007/s00403-002-0324-0 | - |
dc.identifier.pmid | 12115024 | - |
dc.identifier.scopus | 2-s2.0-0036020329 | - |
dc.relation.pages | 214-220 | en_US |
dc.relation.journalvolume | 294 | en_US |
dc.relation.journalissue | 5 | en_US |
item.languageiso639-1 | en | - |
item.openairetype | journal article | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Dermatology | - |
crisitem.author.dept | Dermatology-NTUH | - |
crisitem.author.dept | Clinical Laboratory Sciences and Medical Biotechnology | - |
crisitem.author.dept | Biomedical Engineering | - |
crisitem.author.dept | Dermatology | - |
crisitem.author.dept | Dermatology-NTUH | - |
crisitem.author.dept | Medical Research | - |
crisitem.author.dept | Center for Frontier Medicine | - |
crisitem.author.dept | Pediatrics | - |
crisitem.author.dept | Pediatrics-NTUH | - |
crisitem.author.dept | Clinical Medicine | - |
crisitem.author.dept | Oral Biology | - |
crisitem.author.dept | College of Life Science | - |
crisitem.author.dept | Immunology | - |
crisitem.author.dept | Dermatology | - |
crisitem.author.dept | Dermatology | - |
crisitem.author.dept | Dermatology-NTUH | - |
crisitem.author.orcid | 0000-0002-1498-1474 | - |
crisitem.author.orcid | 0000-0002-6990-3297 | - |
crisitem.author.orcid | 0000-0003-1325-3464 | - |
crisitem.author.orcid | 0000-0002-6705-0286 | - |
crisitem.author.orcid | 0000-0001-6737-6297 | - |
crisitem.author.orcid | 0000-0002-9370-3279 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Engineering | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
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