https://scholars.lib.ntu.edu.tw/handle/123456789/438491
標題: | Crowdsourced estimation of cognitive decline and resilience in Alzheimer's disease | 作者: | Allen G.I. Amoroso N. Anghel C. Balagurusamy V. Bare C.J. Beaton D. Bellotti R. Bennett D.A. Boehme K.L. Boutros P.C. Caberlotto L. Zhan X. Zhou Y. Zhu F. Zhu H. Zhu S. Chen, C.-Y. Caloian C. Campbell F. Chaibub Neto E. Chang Y.-C. Chen B. Chen C.-Y. Chien T.-Y. Clark T. Das S. Davatzikos C. Deng J. Dillenberger D. Dobson R.J.B. Dong Q. Doshi J. Duma D. Errico R. Erus G. Everett E. Fardo D.W. Friend S.H. Fr?hlich H. Gan J. St George-Hyslop P. Ghosh S.S. Glaab E. Green R.C. Guan Y. Hong M.-Y. Huang C. Hwang J. Ibrahim J. Inglese P. Iyappan A. Jiang Q. Katsumata Y. Kauwe J.S.K. Klein A. Kong D. Krause R. Lalonde E. Lauria M. Lee E. Lin X. Liu Z. Livingstone J. Logsdon B.A. Lovestone S. Ma T.-W. Malhotra A. Mangravite L.M. Maxwell T.J. Merrill E. Nagorski J. Namasivayam A. Narayan M. Naz M. Newhouse S.J. Norman T.C. Nurtdinov R.N. YEN-JEN OYANG Pawitan Y. Peng S. Peters M.A. Piccolo S.R. Praveen P. Priami C. Sabelnykova V.Y. Senger P. Shen X. Simmons A. Sotiras A. Stolovitzky G. Tangaro S. Tateo A. Tung Y.-A. Tustison N.J. Varol E. Vradenburg G. Weiner M.W. Xiao G. Xie L. Xie Y. Xu J. CHIEN-YU CHEN |
公開日期: | 2016 | 卷: | 12 | 期: | 6 | 起(迄)頁: | 645-653 | 來源出版物: | Alzheimer's and Dementia | 摘要: | Identifying accurate biomarkers of cognitive decline is essential for advancing early diagnosis and prevention therapies in Alzheimer's disease. The Alzheimer's disease DREAM Challenge was designed as a computational crowdsourced project to benchmark the current state-of-The-art in predicting cognitive outcomes in Alzheimer's disease based on high dimensional, publicly available genetic and structural imaging data. This meta-analysis failed to identify a meaningful predictor developed from either data modality, suggesting that alternate approaches should be considered for prediction of cognitive performance. ? 2016 The Authors. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/438491 | ISSN: | 15525260 | DOI: | 10.1016/j.jalz.2016.02.006 | SDG/關鍵字: | Alzheimer disease; Article; cognitive defect; coping behavior; crowdsourcing; human; meta analysis; Mini Mental State Examination; neuroimaging; nuclear magnetic resonance imaging; prediction; priority journal; Alzheimer disease; bibliographic database; biology; Cognition Disorders; complication; genetics; predictive value; statistics and numerical data; apolipoprotein E; biological marker; Alzheimer Disease; Apolipoproteins E; Biomarkers; Cognition Disorders; Computational Biology; Databases, Bibliographic; Humans; Predictive Value of Tests |
顯示於: | 生物機電工程學系 |
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