https://scholars.lib.ntu.edu.tw/handle/123456789/438983
標題: | Occult hepatitis B virus and surface antigen mutant infection in healthy vaccinated cohorts and children with various forms of hepatitis and multiple transfusions | 作者: | Hung W.-L. JIA-FENG WU YEN-HSUAN NI HUEY-LING CHEN Chiang C.-L. MEI-HWEI CHANG HONG-YUAN HSU |
公開日期: | 2019 | 出版社: | Blackwell Publishing Ltd | 卷: | 39 | 期: | 6 | 起(迄)頁: | 1052-1061 | 來源出版物: | Liver International | 摘要: | Background and Aims: Despite the success of universal infant immunization initiated in Taiwan in 1984, occult hepatitis B virus infection (OBI) and circulating surface antigen mutants remain potential obstacles for eventual eradication of HBV infection. Methods: From 3299 apparently healthy, neonatally–vaccinated subjects (<30 years of age) enrolled during 2014 serosurvey, we recruited all HBsAg–positive (n?=?17), all HBsAg–negative but anti-HBc–positive (n?=?132) and randomly selected HBsAg–negative and anti-HBc–negative subjects (n?=?411). These recruited subjects and 81 HBsAg–negative children with various forms of hepatitis and multiple transfusions were analysed for serum HBV DNA. Results: In healthy, HBsAg–negative subjects, OBI frequency was higher in anti-HBc–positive than anti-HBc-negative individuals (8/90[8.9%] vs 8/301[2.7%], P?=?0.0192) aged <18-years, but was not different between anti-HBc–positive and anti-HBc–negative individuals (0/11[0%] vs 3/110[2.7%], P?>?0.05) aged 18 to 30 years. OBI occurred more frequently in children of HBsAg–positive mothers than in children of HBsAg–negative mothers (10/101 [9.9%] vs 1/75 [1.3%], P?=?0.025). The prevalence of surface ‘a’ determinant (aa110-160) mutants was 13.3% (2/15) in OBI subjects compared to 36.4% (4/11) in HBsAg–positive subjects (P?>?0.05). OBI was found in 30% (3/10) of serologic ‘non-A to E’ viral hepatitis, 14.3% (3/21) of chronic hepatitis C and 2.0% (1/50) of multitransfused, thalassemic children. Conclusions: In this highly immunized population, surface antigen mutant infection is uncommon and has low contribution to OBI development. HBsAg screening plus highly sensitive HBV DNA assays are needed for assurance of blood supply safety. Multiple transfusions from HBsAg–negative blood donors rarely result in persistent HBV infection. HBV might be related to some of serologic ‘non-A to E’ viral hepatitis. ? 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85062704139&doi=10.1111%2fliv.14076&partnerID=40&md5=04aae9d5d642756c7f9003e2e8594cbf https://scholars.lib.ntu.edu.tw/handle/123456789/438983 |
ISSN: | 1478-3223 | DOI: | 10.1111/liv.14076 | SDG/關鍵字: | h b vax ii; hepatitis B antibody; hepatitis B surface antigen; hepatitis B vaccine; recombinant hepatitis B vaccine; virus DNA; hepatitis B surface antigen; hepatitis B vaccine; Article; child; chronic hepatitis C; clinical article; female; genotype; hepatitis B; Hepatitis B virus; human; immunoassay; infant; male; mother; nested polymerase chain reaction; nonhuman; sensitivity and specificity; thalassemia; transfusion; virus hepatitis; adolescent; adult; blood; genetics; hepatitis B; Hepatitis B virus; newborn; preschool child; Taiwan; vaccination; young adult; Adolescent; Adult; Child; Child, Preschool; Female; Hepatitis B; Hepatitis B Antibodies; Hepatitis B Surface Antigens; Hepatitis B Vaccines; Hepatitis B virus; Humans; Infant; Infant, Newborn; Male; Taiwan; Vaccination; Young Adult |
顯示於: | 醫學教育暨生醫倫理學科所 |
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