https://scholars.lib.ntu.edu.tw/handle/123456789/439075
標題: | Prognostic role of p27Kip1 expression in oral squamous cell carcinoma in Taiwan | 作者: | YEN-PING KUO HONG-YUAN HSU SANG-HENG KOK Kuo R.-C. Yang H. Hahn L.-J. CHUN-PIN CHIANG |
公開日期: | 2002 | 卷: | 38 | 期: | 2 | 起(迄)頁: | 172-178 | 來源出版物: | Oral Oncology | 摘要: | The cyclin-dependent kinase inhibitor p27Kip1 can inhibit the G1 to S transition of the cell cycle and is a putative tumor suppressor. Decreased expression of p27Kip1 protein has been correlated with poor prognosis in a variety of human tumors. We examined the expression of p27Kip1 in oral squamous cell carcinoma (SCC), epithelial dysplasia (ED) and normal oral mucosa (NOM) using antibodies to p27Kip1. Positive p27Kip1 nuclear staining was detected in all the specimems from ED and NOM, whereas positive p27Kip1 staining was observed in 16 of the 63 (25%) cases of oral SCC. The labeling index for p27Kip1 protein was significantly reduced from NOM through ED to oral SCCs, indicating that changes of p27Kip1 protein expression may be an early event in oral carcinogenesis in Taiwan. The Kaplan-Meier analysis showed patients with p27Kip1-positive tumors had significantly higher overall survival than those with p27Kip1-negative tumors in a total of 63 patients (P=0.015) and 47 patients with areca quid chewing habit (P=0.026). Multivariate analysis showed decreased p27Kip1 protein expression was an independent significant predictor of poor overall survival in the patients with oral SCCs. These results indicate that p27Kip1 protein expression may serve as a putative new adjuvant prognostic marker for routine assessment of oral SCC patients. ? 2002 Elsevier Science Ltd. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0036175271&doi=10.1016%2fS1368-8375%2801%2900041-0&partnerID=40&md5=6ad4400e5424ce7b8b7602af3b5fd896 https://scholars.lib.ntu.edu.tw/handle/123456789/439075 |
ISSN: | 1368-8375 | DOI: | 10.1016/S1368-8375(01)00041-0 | SDG/關鍵字: | cyclin dependent kinase inhibitor; cyclin dependent kinase inhibitor 1B; monoclonal antibody; unclassified drug; adult; aged; article; betel nut; cancer survival; carcinogenesis; cell nucleus; controlled study; disease marker; dysplasia; epithelium cell; female; habit; human; human tissue; Kaplan Meier method; labeling index; major clinical study; male; mastication; mouth carcinoma; mouth mucosa; multivariate analysis; priority journal; prognosis; protein expression; squamous cell carcinoma; staining; Taiwan; Adult; Aged; Areca; Carcinoma, Squamous Cell; Cell Cycle Proteins; Cyclin-Dependent Kinase Inhibitor p27; Cyclin-Dependent Kinases; Enzyme Inhibitors; Female; Humans; Male; Middle Aged; Mouth Mucosa; Mouth Neoplasms; Precancerous Conditions; Prognosis; Risk Factors; Survival Rate; Tumor Markers, Biological; Tumor Suppressor Proteins |
顯示於: | 醫學教育暨生醫倫理學科所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。