https://scholars.lib.ntu.edu.tw/handle/123456789/439090
Title: | Long-term follow-up of duodenal ulcer in children before and after eradication of Helicobacter pylori | Authors: | Huang F.-C. MEI-HWEI CHANG HONG-YUAN HSU PING-ING LEE CHIA-TUNG SHUN |
Issue Date: | 1999 | Journal Volume: | 28 | Journal Issue: | 1 | Start page/Pages: | 76-80 | Source: | Journal of Pediatric Gastroenterology and Nutrition | Abstract: | Background: Helicobacter pylori is a well-known cause of chronic antral gastritis and plays an important role in the pathogenesis of peptic ulcer disease in adults. However, because of the relatively low incidence of duodenal ulcer in childhood, few studies have been directed specifically at the relation between the treatment of H. pylori infection and duodenal ulcer in children. An evaluation in a larger patient population is necessary to draw a conclusion. Methods: Twenty-six children with duodenal ulcer and H. pylori antral gastritis received triple therapy (amoxicillin, bismuth, and metronidazole) to investigate whether eradication of the organisms can promote healing and prevent relapse of the ulcers in children. Endoscopic examinations were performed before, 2 months, and 12 months after the beginning of treatment. Results: H. pylori infection was eradicated in 25 (96%) of the 26 patients who underwent upper endoscopic follow-up. Clinical improvement and ulcer healing were achieved in 24 (92%) of 26 children. During a mean follow-up of nearly 2 years, the annual ulcer relapse rate was estimated to be 9%. Conclusions: Triple therapy is the treatment of choice for endoscopically proven duodenal ulcer and histologically proven H. pylori antral gastritis in children. It strongly supports a causal relation between H. pylori and duodenal ulcer disease in children. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0032973917&doi=10.1097%2f00005176-199901000-00017&partnerID=40&md5=4afa61ea72e7e2d2dbc6e96202c87151 https://scholars.lib.ntu.edu.tw/handle/123456789/439090 |
ISSN: | 0277-2116 | DOI: | 10.1097/00005176-199901000-00017 | SDG/Keyword: | amoxicillin; bismuth; metronidazole; sucralfate; adolescent; article; bacterial infection; child; clinical article; diarrhea; drug effect; drug efficacy; duodenum ulcer; female; follow up; gastrointestinal endoscopy; helicobacter pylori; human; male; nausea; priority journal; stomach mucosa; ulcer healing; vertigo; vomiting; Adolescent; Amoxicillin; Anti-Bacterial Agents; Biopsy; Bismuth; Child; Disease Progression; Drug Therapy, Combination; Duodenal Ulcer; Female; Follow-Up Studies; Gastrointestinal Agents; Helicobacter Infections; Helicobacter pylori; Humans; Male; Metronidazole; Bacteria (microorganisms); Helicobacter pylori |
Appears in Collections: | 醫學教育暨生醫倫理學科所 |
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