https://scholars.lib.ntu.edu.tw/handle/123456789/439098
標題: | Non-A, non-B, non-C hepatitis: Its significance in pediatric patients and the role of GB virus-C | 作者: | Lai M.-W. MEI-HWEI CHANG HONG-YUAN HSU |
公開日期: | 1997 | 出版社: | Mosby Inc. | 卷: | 131 | 期: | 4 | 起(迄)頁: | 536-540 | 來源出版物: | Journal of Pediatrics | 摘要: | Objectives: To delineate the importance of non-A, non-B, non-C (non- ABC) hepatitis, and the role of GB virus C (GBV-C) in children. Methods: From 1980 to 1995, acute-onset viral hepatitis was diagnosed in 166 inpatients and categorized into type A, B, C, and non-ABC hepatitis according to the serologic markers or the results of polymerase chain reaction assay for HBV DNA or HCV ribonucleic acid (RNA) in the National Taiwan University Hospital. Non-ABC hepatitis was diagnosed in 57 patients (34%). GBV-C RNA was investigated by reverse transcription and nested polymerase chain reaction in 32 of the 57 patients with non-ABC hepatitis. The clinical and laboratory features of patients with acute non-ABC hepatitis were compared with the features of those with acute hepatitis A and B. Results: The degree of abnormality in aminotransferase activities was milder in patients with non- ABC hepatitis than in those with hepatitis B; chronicity was noted in 12%. Fulminant hepatitis occurred in 16%, and the mortality rate was 56%. Young age carried a significantly higher risk of having a fulminant course (1.9 ± 0.2 years of age vs 6.4 ± 5.1 years of age in acute course; p < 0.05). Compared with fulminant hepatitis B, fulminant non-ABC hepatitis had a trend of a longer interval from onset to death (119.2 ± 144.8 vs 15.2 ± 8.4 days; p = 0.079). GBV-C RNA was detected in only two of the patients tested, both of whom had received transfusions; one had persistent viremia and fluctuating aminotransferase values. Conclusions: Non-ABC hepatitis plays an important role in the etiology of pediatric vital hepatitis; however, the role of GBV- C is minor. A search for other unknown viral agent(s) responsible for non- ABCG hepatitis is needed. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0031441987&doi=10.1016%2fS0022-3476%2897%2970057-X&partnerID=40&md5=45db32e94981fcbb899c5fc03d0acb88 https://scholars.lib.ntu.edu.tw/handle/123456789/439098 |
ISSN: | 0022-3476 | DOI: | 10.1016/S0022-3476(97)70057-X | SDG/關鍵字: | aminotransferase; adolescent; article; child; controlled study; enzyme activity; hepatitis A; hepatitis B; hepatitis C; Hepatitis G virus; human; infant; major clinical study; mortality; polymerase chain reaction; priority journal; reverse transcription polymerase chain reaction; serodiagnosis; viremia; virus hepatitis |
顯示於: | 醫學教育暨生醫倫理學科所 |
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