https://scholars.lib.ntu.edu.tw/handle/123456789/439113
標題: | Precore mutant of hepatitis b virus in childhood fulminant hepatitis b: An infrequent association | 作者: | HONG-YUAN HSU MEI-HWEI CHANG CHIN-YUN LEE Hsieh K.-H. YEN-HSUAN NI PEI-JER CHEN DING-SHINN CHEN |
公開日期: | 1995 | 卷: | 171 | 期: | 4 | 起(迄)頁: | 776-781 | 來源出版物: | Journal of Infectious Diseases | 摘要: | Serum HBV DNA from infants and children with fulminant hepatitis B (FHB) or acute selflimiting hepatitis B (AHB) and patients believed to be contamination sources was amplified by polymerase chain reaction (Pf.R) followed by direct sequencing of the precore region. A precore mutation from G to A at nucleotide 1896 was found in 5 of 14 FHB patients and in 3 of 10 AHB patients. Among the 10 infants who developed hepatitis during the first 6 months of age, the precore mutation was detected in only 2 of 7 with FHB and in 1 of 3 with AHB. In 1 infant with FHB, a shift from wild type to precore mutant predominance occurred in the serum virus population during the incubation period. Thus, the precore mutation is neither necessary nor sufficient to cause FHB in childhood, although its contributory role cannot be excluded. Factors other than precore mutations may be important in the pathogenesis of FHB. ? 1995, by The University of Chicago. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028957055&doi=10.1093%2finfdis%2f171.4.776&partnerID=40&md5=46558bd38dc2b34d93ae9c06a0cf0759 https://scholars.lib.ntu.edu.tw/handle/123456789/439113 |
ISSN: | 0022-1899 | DOI: | 10.1093/infdis/171.4.776 | SDG/關鍵字: | hepatitis b surface antigen; immunoglobulin m; virus dna; adolescent; article; child; clinical article; dna sequence; female; gene mutation; genetic association; hepatitis b virus; human; human cell; human tissue; incubation time; infant; male; pathogenesis; polymerase chain reaction; priority journal; strain difference; viremia; virus mutation; Acute Disease; Adolescent; Base Sequence; Carrier State; Child; Child, Preschool; DNA Mutational Analysis; DNA, Viral; Female; Genome, Viral; Hepatic Encephalopathy; Hepatitis B; Hepatitis B Antigens; Hepatitis B Virus; Human; Infant; Male; Molecular Sequence Data; Point Mutation; Support, Non-U.S. Gov't; Taiwan |
顯示於: | 醫學教育暨生醫倫理學科所 |
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