https://scholars.lib.ntu.edu.tw/handle/123456789/444418
標題: | Overexpression of Kynurenine 3-Monooxygenase Correlates with Cancer Malignancy and Predicts Poor Prognosis in Canine Mammary Gland Tumors | 作者: | Chiu Y.-H. Lei H.-J. Huang K.-C. Chiang Y.-L. CHEN-SI LIN Li C.-J. |
公開日期: | 2019 | 卷: | 2019 | 來源出版物: | Journal of Oncology | 摘要: | Tumor biomarkers are developed to indicate tumor status, clinical outcome, or prognosis. Since currently there are no effective biomarkers for canine mammary tumor (CMT), this study intended to verify whether kynurenine 3-monooxygenase (KMO), one of the key enzymes involved in tryptophan catabolism, is competent for predicting prognosis in patients with CMT. By investigating a series of 86 CMT clinical cases, we found that both gene and protein expression of KMO discriminated malignant from benign CMTs and was significantly higher in stage IV and V tumors than in lower-stage CMTs. About 73.7% of malignant CMTs showed strong expression of KMO which correlated with lower overall survival rates in patients. Further, downregulation of KMO activity significantly inhibited cell proliferation of CMT cells. Taken together, the findings indicated that KMO is a potential biomarker for tumor diagnosis, and this might open up new perspectives for clinical applications of CMT. ? 2019 Yi-Han Chiu et al. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/444418 | ISSN: | 1687-8450 | DOI: | 10.1155/2019/6201764 | SDG/關鍵字: | actin; complementary DNA; hypoxanthine phosphoribosyltransferase; indoleamine 2,3 dioxygenase; kynurenine 3 monooxygenase; animal cell; animal experiment; animal model; animal tissue; Article; breast tumor; cancer patient; cancer prognosis; cancer survival; cell proliferation; child; clinical outcome; comparative study; controlled study; down regulation; enzyme activity; follow up; gene expression level; gene overexpression; human; major clinical study; nonhuman; overall survival; protein expression; survival prediction; tumor growth; tumor recurrence |
顯示於: | 獸醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。