https://scholars.lib.ntu.edu.tw/handle/123456789/448845
標題: | Toxicokinetics/toxicodynamics with damage feedback improves risk assessment for tilapia and freshwater clam exposed to arsenic | 作者: | Chen W.-Y. CHUNG-MIN LIAO Ju Y.-R. Singh S. Jou L.-J. Chen B.-C. Tsai J.-W. |
關鍵字: | Arsenic; Damage feedback; Ecotoxicology; Freshwater Clam; Tilapia; Toxicodynamics; Toxicokinetics | 公開日期: | 2012 | 卷: | 21 | 期: | 2 | 起(迄)頁: | 485-495 | 來源出版物: | Ecotoxicology | 摘要: | It has been proposed that irreversible responses of organisms exposed to contaminants are due to a systemslevel feedback. Here we tested this hypothesis by reanalyzing the published data on toxicokinetics and survival probability based on a systems-level threshold damage model (TDM) incorporating with a positive damage feedback to explore the steady-state response and dynamic behavior of damage for tilapia and freshwater clam exposed to waterborne arsenic (As). We found that ultrasensitivity appeared in As-tilapia and freshwater clam systems with Hill coefficient n C 4, indicating that the positive damage feedback mechanism has been triggered. We confirmed that damage can trigger a positive feedback loop that together with As stressor increases irreversibility. This study also showed that TDM with positive feedback gave a much better predictability than that of TDM at As concentrations ranging from 100 to 500 mg l-1 for freshwater clam, whereas for tilapia, two models had nearly same performance on predictability. We suggested that mortality-time profile derived Hill coefficient could be used as a new risk indicator to assess the survival probability for species exposed to waterborne metals. We anticipated that the proposed toxicokinetics/toxicodynamics with a positive damage feedback may facilitate our understanding and manipulation of complex mechanisms of metal susceptibility among species and improve current risk assessment strategies. © 2011 Springer Science+Business Media, LLC. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/448845 | ISSN: | 0963-9292 | DOI: | 10.1007/s10646-011-0810-2 | SDG/關鍵字: | arsenic; fresh water; organoarsenic derivative; arsenic; ecotoxicology; feedback mechanism; fish; freshwater ecosystem; mollusc; numerical model; risk assessment; article; clam; concentration (parameters); mortality; positive feedback; priority journal; risk assessment; sensitivity analysis; statistical model; survival prediction; Tilapia; toxicodynamics; toxicokinetics; toxicology; animal; aquaculture; bivalve; differential threshold; drug effect; feedback system; longevity; physiology; predictive value; Bivalvia; Tilapia; Animals; Aquaculture; Arsenicals; Bivalvia; Differential Threshold; Feedback, Physiological; Fresh Water; Longevity; Predictive Value of Tests; Risk Assessment; Tilapia |
顯示於: | 生物環境系統工程學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。