https://scholars.lib.ntu.edu.tw/handle/123456789/452187
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Lin C.-Y. | en_US |
dc.contributor.author | Huang Y.-L. | en_US |
dc.contributor.author | Li J.-R. | en_US |
dc.contributor.author | FU-HSIUNG CHANG | en_US |
dc.contributor.author | Win-Li Lin | en_US |
dc.creator | Lin C.-Y.;Huang Y.-L.;Li J.-R.;Fu-Hsiung Chang;Lin W.-L. | - |
dc.date.accessioned | 2020-01-21T06:05:57Z | - |
dc.date.available | 2020-01-21T06:05:57Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 03015629 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-77956053538&doi=10.1016%2fj.ultrasmedbio.2010.06.003&partnerID=40&md5=10c74dea8c620e7c588cf433b502f3cb | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/452187 | - |
dc.description.abstract | Ultrasound sonication with microbubbles (MBs) was evaluated for enhancement of the release of nanoparticles from vasculature to tumor tissues. In this study, tumor-bearing Balb/c mice were insonicated with focused ultrasound (FUS) in the tumors after the injection of MBs (SonoVue?) and then lipid-coated quantum dot (LQD) nanoparticles (130 ± 25 nm) were injected through the tail vein. We studied the effects of the injected MB dose (0-300 μL/kg), sonication duration (0-300 s) and treatment-procedure sequence on the accumulation of nanoparticles in the tumors 24 h after the treatment and the time response of the accumulation (0.5-24 h). After the treatment, the mice were sacrificed and perfused and then the tumor tissues were harvested for quantifying the amount of nanoparticles using graphite furnace atomic absorption spectrometry (GF-AAS). The results showed that pulsed-FUS sonication with MBs can effectively enhance the vascular permeability for LQD nanoparticle delivery into the sonicated tumors. It indicates that this technique is promising for a better nanodrug delivery for tumor chemotherapy. ? 2010 World Federation for Ultrasound in Medicine & Biology. | - |
dc.relation.ispartof | Ultrasound in Medicine and Biology | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | BALB/c mice; Delivery enhancement; Focused ultrasound; Graphite furnace atomic absorption spectrometry; Microbubbles; Mouse tumors; Quantum Dot; Tail veins; Time response; Tumor tissues; Ultrasound sonications; Vascular permeability; Vasculature; Absorption spectroscopy; Atomic absorption spectrometry; Chemotherapy; Histology; Nanoparticles; Sonication; Ultrasonic applications; Ultrasonics; Tumors; lipid; nanoparticle; quantum dot; sonovue; animal cell; animal experiment; animal model; animal tissue; article; atomic absorption spectrometry; Bagg albino mouse; blood vessel permeability; cancer chemotherapy; cancer tissue; controlled study; dose time effect relation; drug accumulation; drug delivery system; focused ultrasound; male; microbubble; mouse; nonhuman; priority journal; ultrasound; Adenocarcinoma; Animals; Cadmium Compounds; Capillary Permeability; Colorectal Neoplasms; Male; Mice; Mice, Inbred BALB C; Microbubbles; Quantum Dots; Selenium Compounds; Spectrophotometry, Atomic; Time Factors; Tumor Cells, Cultured | - |
dc.title | Effects of focused ultrasound and microbubbles on the vascular permeability of nanoparticles delivered into mouse tumors | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.ultrasmedbio.2010.06.003 | - |
dc.identifier.scopus | 2-s2.0-77956053538 | - |
dc.relation.pages | 1460-1469 | - |
dc.relation.journalvolume | 36 | - |
dc.relation.journalissue | 9 | - |
item.fulltext | no fulltext | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.openairetype | journal article | - |
crisitem.author.dept | Center for Biotechnology | - |
crisitem.author.dept | Biochemistry and Molecular Biology | - |
crisitem.author.parentorg | Others: University-Level Research Centers | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 生物化學暨分子生物學科研究所 |
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