https://scholars.lib.ntu.edu.tw/handle/123456789/452407
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Ko C.-C. | en_US |
dc.contributor.author | Chen Y.-J. | en_US |
dc.contributor.author | Chen C.-T. | en_US |
dc.contributor.author | Liu Y.-C. | en_US |
dc.contributor.author | Cheng F.-C. | en_US |
dc.contributor.author | Hsu K.-C. | en_US |
dc.contributor.author | LU-PING CHOW | en_US |
dc.creator | Ko C.-C.;Chen Y.-J.;Chen C.-T.;Liu Y.-C.;Cheng F.-C.;Hsu K.-C.;Lu-Ping Chow | - |
dc.date.accessioned | 2020-01-22T04:47:50Z | - |
dc.date.available | 2020-01-22T04:47:50Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 00219258 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84905851435&doi=10.1074%2fjbc.M114.553248&partnerID=40&md5=21f9765dc650523fc89d2173e25efc73 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/452407 | - |
dc.description.abstract | Background: Quercetin inhibits prostate cancer growth, but its mechanisms are not fully elucidated. Results: Quercetin binds to hnRNPA1 and hampers its return to the nucleus, causing accumulation of hnRNPA1 in the cytoplasm. Conclusion: hnRNPA1 is a target of quercetin, driving cells toward apoptosis through expression regulation of cIAP1. Significance: Understanding of the novel mechanism of actions on quercetin is crucial for cancer prevention and treatment in prostate cancer. ? 2014 by The American Society for Biochemistry and Molecular Biology, Inc. | - |
dc.publisher | American Society for Biochemistry and Molecular Biology Inc. | - |
dc.relation.ispartof | Journal of Biological Chemistry | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | Cell death; Diseases; Flavonoids; Cancer prevention; Expression regulation; Heterogeneous nuclear ribonucleoprotein (hnRNP); Mechanism of action; Molecular targets; Prostate cancers; Proteomics; Phenols; antineoplastic agent; heterogeneous nuclear ribonucleoprotein; hnRNP A1; inhibitor of apoptosis protein; karyopherin beta; mutant protein; protein binding; quercetin; recombinant protein; TNPO1 protein, human; active transport; amino acid sequence; antagonists and inhibitors; apoptosis; binding site; biological model; cell survival; drug effects; genetics; human; male; metabolism; molecular genetics; phytotherapy; Prostatic Neoplasms; proteomics; tumor cell line; Amino Acid Sequence; Antineoplastic Agents, Phytogenic; Apoptosis; beta Karyopherins; Binding Sites; Biological Transport, Active; Cell Line, Tumor; Cell Survival; Heterogeneous-Nuclear Ribonucleoprotein Group A-B; Humans; Inhibitor of Apoptosis Proteins; Male; Models, Biological; Molecular Sequence Data; Mutant Proteins; Phytotherapy; Prostatic Neoplasms; Protein Binding; Proteomics; Quercetin; Recombinant Proteins | - |
dc.title | Chemical proteomics identifies heterogeneous nuclear ribonucleoprotein (hnRNP) A1 as the molecular target of quercetin in its anti-cancer effects in PC-3 cells | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1074/jbc.M114.553248 | - |
dc.identifier.scopus | 2-s2.0-84905851435 | - |
dc.relation.pages | 22078-22089 | - |
dc.relation.journalvolume | 289 | - |
dc.relation.journalissue | 32 | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Biochemistry and Molecular Biology | - |
crisitem.author.orcid | 0000-0002-4420-211X | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 生物化學暨分子生物學科研究所 |
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