https://scholars.lib.ntu.edu.tw/handle/123456789/452526
標題: | Cytokine regulation networks in the cancer microenvironment | 作者: | BOR-CHING SHEU WEN-CHUN CHANG Cheng C.-Y. HO-HSIUNG LIN DAW-YUAN CHANG Huang S.-C. |
公開日期: | 2008 | 卷: | 13 | 期: | 16 | 起(迄)頁: | 6255-6268 | 來源出版物: | Frontiers in Bioscience | 摘要: | During carcinoma formation, cancer cells release various cytokines and growth factors into their surroundings and recruit and reprogram many other types of cells in order to establish a tumor microenvironment. Consequently, The tumor tissues almost always contain a large number of endothelial cells, fibroblasts, and infiltrating inflammatory cells that in turn produce a variety of cytokines. The cytokines produced by these cells have been posited as key factors in modulating immune responseeither against or in favor of tumorigenesis in the microenvironment. The interactions that take place betweenimmune and cancer cells are complex, involving multiple cascades of cytokines, chemokines, and/or growth factors. In this review, we address the essential pro-and antitumorigenic roles of cytokines in the tumor microenvironment. As the interaction of cytokines, growth factors, and cancer cells forms a comprehensive network at the tumor site that is then responsible for the overallprogression or rejection of the tumor, the current review links the microenvironment-derived cytokines and growth factors to a number of different kinds of human carcinogenesis models. Multifunctional cytokines, extracellular matrix mediators, and regulatory cytokines in the cancer environment are all shown to be key factors in the different cancer immune-editing systems. The characterization of cytokine networks in various types of cancer cells may yield important information for understanding the immune-related mechanisms of cancer development, and this knowledge may have subsequent application in cancer immunotherapy. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-52049108902&partnerID=40&md5=18927f05ebda22b916fd64245263d09f https://scholars.lib.ntu.edu.tw/handle/123456789/452526 |
SDG/關鍵字: | CXCL12 protein, human; cytokine; interferon; stromal cell derived factor 1; TNFSF10 protein, human; transforming growth factor beta; tumor necrosis factor related apoptosis inducing ligand; dendritic cell; human; immunology; neoplasm; pathology; pathophysiology; physiology; review; signal transduction; Chemokine CXCL12; Cytokines; Dendritic Cells; Humans; Interferons; Neoplasms; Signal Transduction; TNF-Related Apoptosis-Inducing Ligand; Transforming Growth Factor beta |
顯示於: | 醫學系 |
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