https://scholars.lib.ntu.edu.tw/handle/123456789/452532
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | BOR-CHING SHEU | en_US |
dc.contributor.author | WEN-HUNG KUO | en_US |
dc.contributor.author | RUEY-JIEN CHEN | en_US |
dc.contributor.author | Huang S.-C. | en_US |
dc.contributor.author | KING-JEN CHANG | en_US |
dc.contributor.author | SONG-NAN CHOW | en_US |
dc.creator | Chow S.-N.;Chang K.-J.;Huang S.-C.;Chen R.-J.;Kuo W.-H.;BOR-CHING SHEU | - |
dc.date.accessioned | 2020-01-22T06:00:26Z | - |
dc.date.available | 2020-01-22T06:00:26Z | - |
dc.date.issued | 2008 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-56649094469&doi=10.1016%2fj.breast.2008.06.001&partnerID=40&md5=345a1636c11aef2c78b958a423bfe6fd | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/452532 | - |
dc.description.abstract | To investigate the clinical significance of tumor-infiltrating lymphocytes (TILs) within the tumor milieu, we quantitatively measured and compared the subpopulations of TILs in 24 patients with stage I-III breast carcinoma. Peripheral blood mononuclear cells (PBMCs), normal breast parenchyma-infiltrating lymphocytes (NILs), and TILs were isolated from tissue specimens and quantified by flow cytometry. The results showed that increased proportion of CD8+ T cells, with decreased proportion of CD4+ T cells, was significant in gated CD3+ TILs as compared to autologous NILs or PBMCs (P < 0.001). The tumor-infiltrating CD8+ T cells significantly increased with stage progression, reflected in a more strongly decreased CD4/CD8 percentage (P = 0.003). The CD4/CD8 percentage of TILs was strongly correlated with lymphovascular permeation and subsequent lymph node metastasis (P < 0.001). Increased percentages of tumor-infiltrating CD8+ T cells with decreased CD4/CD8 percentages are of prognostic importance for cancer progression in human breast cancer. ? 2008 Elsevier Ltd. All rights reserved. | en_US |
dc.relation.ispartof | Breast | en_US |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | CD3 antigen; CD4 antigen; CD8 antigen; article; breast carcinoma; cancer growth; cancer staging; CD4 CD8 ratio; CD4+ T lymphocyte; CD8+ T lymphocyte; cell isolation; clinical article; controlled study; flow cytometry; human; human cell; human tissue; lymph node metastasis; lymphocyte subpopulation; peripheral blood mononuclear cell; priority journal; prognosis; quantitative analysis; tumor associated leukocyte; tumor immunity | - |
dc.title | Clinical significance of tumor-infiltrating lymphocytes in neoplastic progression and lymph node metastasis of human breast cancer | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.breast.2008.06.001 | - |
dc.identifier.scopus | 2-s2.0-56649094469 | - |
dc.relation.pages | 604-610 | en_US |
dc.relation.journalvolume | 17 | en_US |
dc.relation.journalissue | 6 | en_US |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Obstetrics & Gynecology | - |
crisitem.author.dept | Obstetrics & Gynecology-NTUH | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Obstetrics & Gynecology | - |
crisitem.author.dept | Obstetrics & Gynecology-NTUH | - |
crisitem.author.dept | Surgery | - |
crisitem.author.dept | Surgery-NTUH | - |
crisitem.author.dept | Obstetrics & Gynecology | - |
crisitem.author.dept | Obstetrics & Gynecology-NTUH | - |
crisitem.author.orcid | 0000-0003-1278-6082 | - |
crisitem.author.orcid | 0000-0002-9881-4605 | - |
crisitem.author.orcid | 0000-0003-0291-006X | - |
crisitem.author.orcid | 0000-0001-9811-3422 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學系 |
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