https://scholars.lib.ntu.edu.tw/handle/123456789/452565
Title: | Reversed CD4/CD8 ratios of tumor-infiltrating lymphocytes are correlated with the progression of human cervical carcinoma | Authors: | BOR-CHING SHEU Hsu S.-M. HONG-NERNG HO Lin R.-H. PAO-LING TORNG Huang S.-C. |
Issue Date: | 1999 | Journal Volume: | 86 | Journal Issue: | 8 | Start page/Pages: | 1537-1543 | Source: | Cancer | Abstract: | BACKGROUND. To investigate the clinical significance of tumor- infiltrating lymphocytes (TILs)within the tumor milieu of human cervical carcinoma, the authors quantitatively measured and compared the subpopulations of lymphocytes infiltrating the neoplastic cervix. METHODS. A total of 30 patients with Stage Ia-IIa cervical carcinoma were enrolled. TILs were isolated from tissue specimens by means of a mechanical dispersal technique, and the immunocyte subsets were quantified with dual-color flow cytometry. Bulky tumor was defined as tumor size >4 cm in greatest dimension according to the 1995 staging of the International Federation of Gynecology and Obstetrics. RESULTS. The CD4/CD8 ratios of TILs were reversed in both cervical squamous cell carcinoma in = 20) and cervical adenocarcinoma in = 10). The proportion of CD4+ T cells was significantly lower in tumors from patients with lymph node metastasis (n = 8) than in those from patients without lymph node metastasis in = 22) (24.5 vs. 32.7, P = 0.001), as was the reversed CD4/CD8 ratio (0.50 vs. 0.81, P = 0.001). The proportion of CD4+ T cells was much lower in bulky tumors (n = 5) than in nonbulky tumors in = 25) (21.4 vs. 32.5, P < 0 001), reflecting in a more strongly reversed CD4/CD8 ratio (0.41 vs. 0.81, P = 0.001). CONCLUSIONS. Decreased proportions of tumor-infiltrating CD4+ T cells with reversed CD4/CD8 ratios are highly correlated with rapid tumor growth and lymph node metastasis in cervical carcinoma. The regional immune escape is of prognostic importance with regard to cancer progression. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033569833&doi=10.1002%2f%28SICI%291097-0142%2819991015%2986%3a8%3c1537%3a%3aAID-CNCR21%3e3.0.CO%3b2-D&partnerID=40&md5=bcab9cee0e8142120b33d48b6bc1a21b https://scholars.lib.ntu.edu.tw/handle/123456789/452565 |
DOI: | 10.1002/(SICI)1097-0142(19991015)86:8<1537 | SDG/Keyword: | article; cancer growth; cancer staging; clinical article; correlation function; female; human; human tissue; lymph node metastasis; lymphocyte count; priority journal; tumor associated leukocyte; uterine cervix carcinoma; Adenocarcinoma; Antigens, CD4; Antigens, CD8; Carcinoma, Squamous Cell; CD4-CD8 Ratio; Disease Progression; Female; Humans; Immunophenotyping; Killer Cells, Natural; Lymph Nodes; Lymphatic Metastasis; Lymphocyte Count; Lymphocyte Subsets; Lymphocytes, Tumor-Infiltrating; Neoplasm Staging; Uterine Cervical Neoplasms |
Appears in Collections: | 醫學系 |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.