https://scholars.lib.ntu.edu.tw/handle/123456789/452721
標題: | Distinguishing benign from malignant pelvic mass utilizing an algorithm with HE4, menopausal status, and ultrasound findings | 作者: | Wilailak S. Chan K.K.L. CHI-AN CHEN Nam J.-H. Ochiai K. Aw T.-C. Sabaratnam S. Hebbar S. Sickan J. Schodin B.A. Charakorn C. Sumpaico W.W. |
公開日期: | 2015 | 卷: | 46 | 期: | 53 | 起(迄)頁: | 46-53 | 來源出版物: | Journal of Gynecologic Oncology | 摘要: | Objective: The purpose of this study was to develop a risk prediction score for distinguishing benign ovarian mass from malignant tumors using CA-125, human epididymis protein 4 (HE4), ultrasound findings, and menopausal status. The risk prediction score was compared to the risk of malignancy index and risk of ovarian malignancy algorithm (ROMA). Methods: This was a prospective, multicenter (n=6) study with patients from six Asian countries. Patients had a pelvic mass upon imaging and were scheduled to undergo surgery. Serum CA-125 and HE4 were measured on preoperative samples, and ultrasound findings were recorded. Regression analysis was performed and a risk prediction model was developed based on the significant factors. A bootstrap technique was applied to assess the validity of the HE4 model. Results: A total of 414 women with a pelvic mass were enrolled in the study, of which 328 had documented ultrasound findings. The risk prediction model that contained HE4, menopausal status, and ultrasound findings exhibited the best performance compared to models with CA-125 alone, or a combination of CA-125 and HE4. This model classified 77.2% of women with ovarian cancer as medium or high risk, and 86% of women with benign disease as very-low, low, or medium-low risk. This model exhibited better sensitivity than ROMA, but ROMA exhibited better specificity. Both models performed better than CA-125 alone. Conclusion: Combining ultrasound with HE4 can improve the sensitivity for detecting ovarian cancer compared to other algorithms. ? 2015. Asian Society of Gynecologic Oncology, Korean Society of Gynecologic Oncology. All right reserved. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/452721 | DOI: | 10.3802/jgo.2015.26.1.46 | SDG/關鍵字: | CA 125 antigen; human epididymis protein 4; CA 125 antigen; protein; tumor marker; WFDC2 protein, human; adult; Article; Asian; benign ovarian mass; bootstrapping; cancer diagnosis; cancer incidence; cancer risk; cancer staging; clinical assessment tool; diagnostic test accuracy study; disease classification; echography; female; high risk population; human; major clinical study; malignant neoplastic disease; menopause; multicenter study; ovary cancer; ovary carcinoma; postmenopause; preoperative evaluation; prospective study; risk of malignancy index; risk of ovarian malignancy algorithm; scoring system; sensitivity and specificity; algorithm; blood; clinical trial; decision support system; differential diagnosis; echography; middle aged; Ovarian Neoplasms; predictive value; procedures; receiver operating characteristic; risk assessment; Adult; Algorithms; Biomarkers, Tumor; CA-125 Antigen; Decision Support Techniques; Diagnosis, Differential; Female; Humans; Menopause; Middle Aged; Ovarian Neoplasms; Predictive Value of Tests; Prospective Studies; Proteins; Risk Assessment; ROC Curve; Sensitivity and Specificity |
顯示於: | 醫學系 |
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