https://scholars.lib.ntu.edu.tw/handle/123456789/454649
標題: | Lipopolysaccharide increases resistin gene expression in vivo and in vitro | 作者: | SHAO-CHUN LU Shieh W.-Y. Chen C.-Y. Hsu S.-C. Chen H.-L. |
關鍵字: | Adipocyte; Inflammation; Lipopolysaccharide; Monocyte; Resistin | 公開日期: | 2002 | 卷: | 530 | 期: | 1-3 | 起(迄)頁: | 158-162 | 來源出版物: | FEBS Letters | 摘要: | Although resistin has been thought to be an important link between obesity and diabetes, recent results do not support this hypothesis. We speculated that resistin may be involved in inflammatory processes and be induced by inflammatory stimuli. In this study, we tested whether lipopolysaccharide (LPS) induced resistin expression in rats. The results show that resistin mRNA levels in white adipose tissue and white blood cells were increased by LPS treatment. LPS also increased resistin mRNA levels in 3T3-L1 adipocytes and human peripheral blood monocytes. The results suggest that resistin is involved in insulin resistance and probably in other inflammatory responses. ? 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0037163871&doi=10.1016%2fS0014-5793%2802%2903450-6&partnerID=40&md5=305b1bb52f0a4165f2ad8b76b7e9babe https://scholars.lib.ntu.edu.tw/handle/123456789/454649 |
ISSN: | 0014-5793 | DOI: | 10.1016/S0014-5793(02)03450-6 | SDG/關鍵字: | lipopolysaccharide; messenger RNA; resistin; adipocyte; animal cell; animal experiment; animal tissue; article; controlled study; correlation analysis; gene expression regulation; human; human cell; in vitro study; in vivo study; inflammation; insulin resistance; leukocyte; male; monocyte; mouse; nonhuman; normal human; priority journal; protein determination; rat; white adipose tissue; 3T3 Cells; Animals; Base Sequence; DNA Primers; Gene Expression Regulation; Hormones, Ectopic; Hypoglycemic Agents; Intercellular Signaling Peptides and Proteins; Lipopolysaccharides; Male; Mice; Nerve Growth Factor; Proteins; Rats; Rats, Wistar; Resistin; RNA, Messenger; Thiazoles; Thiazolidinediones |
顯示於: | 生物化學暨分子生物學科研究所 |
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