https://scholars.lib.ntu.edu.tw/handle/123456789/454771
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Wang J.M. | en_US |
dc.contributor.author | Huang F.C. | en_US |
dc.contributor.author | Kuo M.H.-J. | en_US |
dc.contributor.author | Wang Z.-F. | en_US |
dc.contributor.author | Tseng T.-Y. | en_US |
dc.contributor.author | Chang L.-C. | en_US |
dc.contributor.author | Yen S.-J. | en_US |
dc.contributor.author | Chang T.-C. | en_US |
dc.contributor.author | JING-JER LIN | en_US |
dc.creator | Wang J.M.;Huang F.C.;Kuo M.H.-J.;Wang Z.-F.;Tseng T.-Y.;Chang L.-C.;Yen S.-J.;Chang T.-C.;Jing-Jer Lin | - |
dc.date.accessioned | 2020-02-06T10:53:29Z | - |
dc.date.available | 2020-02-06T10:53:29Z | - |
dc.date.issued | 2014 | - |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84901436178&doi=10.1074%2fjbc.M114.548230&partnerID=40&md5=d880fc59961757c2eb290a142c7a28c2 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/454771 | - |
dc.description.abstract | Background: The Wnt1 pathway is recognized to play a major role in cancer progression. Results: The promoter region of the WNT1 gene can form G-quadruplex structures, which regulate WNT1 expression and its downstream signaling pathways. Conclusion: The Wnt1-mediated migration and invasion activities of cancer cells are inhibited by G-quadruplex stabilizers. Significance: A pathway-specific strategy is identified to repress cancer metastasis using G-quadruplex stabilizers. ? 2014 by The American Society for Biochemistry and Molecular Biology, Inc. | - |
dc.publisher | American Society for Biochemistry and Molecular Biology Inc. | - |
dc.relation.ispartof | Journal of Biological Chemistry | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | Diseases; Gene expression; Cancer cells; Cancer metastasis; Cancer progression; G-quadruplex structure; G-quadruplexes; Promoter region; Signal pathways; Signaling pathways; Cells; beta catenin; guanine quadruplex; matrilysin; membrane protein; oligonucleotide; protein BMVC; protein BMVC4; survivin; unclassified drug; Wnt1 protein; article; cancer cell; cell invasion; controlled study; down regulation; drug research; gene expression regulation; gene overexpression; human; human cell; melting point; migration inhibition; priority journal; promoter region; protein analysis; protein stability; protein structure; protein targeting; signal transduction; Anticancer Drug; Cell Migration; DNA Structure; G-quadruplex; Promoters; Wnt Pathway; beta Catenin; Carbazoles; Cell Line, Tumor; Cell Movement; G-Quadruplexes; Gene Expression Regulation, Neoplastic; Humans; Immunoblotting; Inhibitor of Apoptosis Proteins; Matrix Metalloproteinase 7; Neoplasm Invasiveness; Oligonucleotides; Promoter Regions, Genetic; Pyrazines; Pyridinium Compounds; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Wnt1 Protein | - |
dc.title | Inhibition of cancer cell migration and invasion through suppressing the wnt1-mediating signal pathway by G-quadruplex structure stabilizers | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1074/jbc.M114.548230 | - |
dc.identifier.scopus | 2-s2.0-84901436178 | - |
dc.relation.pages | 14612-14623 | - |
dc.relation.journalvolume | 289 | - |
dc.relation.journalissue | 21 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.fulltext | no fulltext | - |
crisitem.author.dept | Biochemistry and Molecular Biology | - |
crisitem.author.dept | Pharmacology | - |
crisitem.author.orcid | 0000-0001-8250-7398 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 生物化學暨分子生物學科研究所 |
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