https://scholars.lib.ntu.edu.tw/handle/123456789/455426
標題: | Scavenging effect of benzophenones on the oxidative stress of skeletal muscle cells | 作者: | JUI-SHENG SUN Shieh K.-M. Chiang H.-C. Sheu S.-Y. Hang Y.-S. Lu F.-J. Tsuang Y.-H. |
公開日期: | 1999 | 卷: | 26 | 起(迄)頁: | 1100-1107 | 來源出版物: | Free Radical Biology and Medicine | 摘要: | Benzophenone is an ultraviolet (UV)-absorbing agent that has been used in industry and medicine for more than 30 years. Consumers of cosmetics and sunscreens containing UV-absorbers are exposed to benzophenones on a daily basis, owing to the widespread use of these compounds. However, the efficacy of these compounds as scavengers of oxidative stress is still not well established. In the present study, we investigate the antioxidative capacity of six sunscreen benzophenone compounds. A primary myoblast culture was mixed in vitro with 100 μM menadione. The cytotoxic effect by menadione-induced oxidative stress was monitored by the lucigenin- or luminol-amplified chemiluminescence, methylthiotetrazole (MTT) assay, and the antioxidative effects of various benzophenone compounds were evaluated. The results showed that the addition of menadione can induce oxidative stress on myoblasts by superoxide and hydrogen peroxide production, which can be eradicated by superoxide dismutase (SOD) and catalase, respectively, in a dose-dependent mode. The catalase has a protective effect on the cytotoxicity induced by menadione as measured by the MTT assay, while the SOD does not. The selected benzophenones also have a significant scavenging effect on the menadione- induced cell death on the myoblasts. The ortho-dihydroxyl structure and other hydroxy groups in the same ring have a stronger scavenging effect on the superoxide anion on myoblasts; thus, a stable penoxy radical may be formed. The mechanism of this effect remains to be clarified. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033020998&doi=10.1016%2fS0891-5849%2898%2900297-4&partnerID=40&md5=722d556eb6ccb4d159e6e35dbbe6c089 https://scholars.lib.ntu.edu.tw/handle/123456789/455426 |
ISSN: | 0891-5849 | DOI: | 10.1016/S0891-5849(98)00297-4 | SDG/關鍵字: | 2,2' dihydroxybenzophenone; 2,2',4,4' tetrahydroxybenzophenone; 2,3',4,4' tetrahydroxybenzophenone; 2,3,4 trihydroxybenzophenone; 2,4,4' trihydroxybenzophenone; 3,4,5,2',3',4' hexahydroxybenzophenone; 4,4' dihydroxybenzophenone; benzophenone derivative; benzoresorcinol; catalase; menadione; scavenger; superoxide dismutase; unclassified drug; animal cell; antioxidant activity; article; colorimetry; controlled study; drug activity; drug screening; female; male; myoblast; newborn; nonhuman; oxidative stress; priority journal; rat; scavenging system; skeletal muscle; Acridines; Animals; Benzophenones; Cell Survival; Chemiluminescent Measurements; Drug Evaluation, Preclinical; Free Radical Scavengers; Humans; Luminol; Muscle, Skeletal; Oxidative Stress; Rats; Sunscreening Agents; Superoxide Dismutase; Tetrazolium Salts; Thiazoles; Vitamin K; Animalia; Lethrinidae |
顯示於: | 醫學系 |
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