https://scholars.lib.ntu.edu.tw/handle/123456789/455569
標題: | Circadian variations in plasma neutral and basic amino acid concentrations in young men on an ordinary Taiwanese diet | 作者: | Tsai P.-J. Wu W.-H. PO-CHAO HUANG |
關鍵字: | Basic amino acid; Circadian variation; Neutral amino acid; Plasma | 公開日期: | 2000 | 卷: | 99 | 期: | 2 | 起(迄)頁: | 151-157 | 來源出版物: | Journal of the Formosan Medical Association | 摘要: | Background and purpose: Plasma levels of circulating free amino acids reflect the net status of protein breakdown and synthesis, and may be linked to various disease states. We studied circadian variations in plasma concentrations of neutral and basic amino acids during a 24-hour period in healthy young men who consumed ordinary Taiwanese test meals. Methods: Ten subjects ingested the test diet (protein intake, 1.5 g · kg-1 · d-1) which was offered in three meals and two light snacks during the day. Thirteen heparinized blood samples were collected from each subject to analyze plasma amino acid concentrations during the experimental period, at 1- to 3-hour intervals. Results: The plasma concentrations of all neutral amino acids, including the large neutral amino acids (leucine, isoleucine, valine, tryptophan, tyrosine, and phenylalanine) and methionine, as well as the small neutral amino acids (glycine, serine, threonine, and proline) and the basic amino acids (histidine, arginine, lysine), varied significantly as a function of the time of day (p < 0.001). Except for glycine and proline, all of the neutral amino acids exhibited a marked evening elevation after dinner, with the highest plasma concentration at 23:00. Proline showed peak concentrations at 09:00, while glycine and the basic amino acids exhibited peak concentrations at 21:00. Most of the plasma amino acids exhibited the lowest concentrations at 12:00. Conclusion: Plasma neutral and basic amino acid concentrations exhibited significant circadian variations. The present study also provided the mean fasting plasma levels of amino acids in healthy young men consuming an ordinary Taiwanese diet. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0034072366&partnerID=40&md5=64559f5589b8e255ca84f039e76ef8c8 https://scholars.lib.ntu.edu.tw/handle/123456789/455569 |
ISSN: | 0929-6646 | SDG/關鍵字: | amino acid; adult; amino acid blood level; article; circadian rhythm; diet; human; human experiment; male; protein degradation; protein intake; protein synthesis; Taiwan; Adult; Amino Acids; Circadian Rhythm; Diet; Humans; Male |
顯示於: | 生物化學暨分子生物學科研究所 |
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