https://scholars.lib.ntu.edu.tw/handle/123456789/456351
標題: | Rare-earth-doped calcium carbonate exposed to x-ray irradiation to induce reactive oxygen species for tumor treatment | 作者: | Yang, Chun-Chen Wang, Wei-Yun Lin, Feng-Huei CHUN-HAN HOU |
關鍵字: | Alternative tumor treatment;Calcium carbonate;Cerium;X-ray | 公開日期: | 1-三月-2019 | 出版社: | MDPI AG | 卷: | 20 | 期: | 5 | 來源出版物: | International Journal of Molecular Sciences | 摘要: | Conventional photodynamic therapy (PDT) is limited by its penetration depth due to the photosensitizer and light source. In this study, we developed X-ray induced photodynamic therapy that applied X-ray as the light source to activate Ce-doped CaCO3 (CaCO3:Ce) to generate an intracellular reactive oxygen species (ROS) for killing cancer cells. The A549 cell line was used as the in vitro and in vivo model to evaluate the efficacy of X-ray-induced CaCO3:Ce. The cell viability significantly decreased and cell cytotoxicity obviously increased with CaCO3:Ce exposure under X-ray irradiation, which is less harmful than radiotherapy in tumor treatment. CaCO3:Ce produced significant ROS under X-ray irradiation and promoted A549 cancer cell death. CaCO3:Ce can enhance the efficacy of X-ray induced PDT, and tumor growth was inhibited in vivo. The blood analysis and hematoxylin and eosin stain (H&E) stain fully supported the safety of the treatment. The mechanisms underlying ROS and CO2 generation by CaCO3:Ce activated by X-ray irradiation to induce cell toxicity, thereby inhibiting tumor growth, is discussed. These findings and advances are of great importance in providing a novel therapeutic approach as an alternative tumor treatment. © 2019 by the authors. Licensee MDPI, Basel, Switzerland. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85062601114&doi=10.3390%2fijms20051148&partnerID=40&md5=e6682974d5ff69d551640115a8a75182 https://scholars.lib.ntu.edu.tw/handle/123456789/456351 |
ISSN: | 1661-6596 | DOI: | 10.3390/ijms20051148 |
顯示於: | 醫學系 |
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