https://scholars.lib.ntu.edu.tw/handle/123456789/457880
標題: | Diagnostic value of 18F-FDG-PET/CT in indeterminate infiltrative hepatic lesions in an endemic area of viral hepatitis | 作者: | MEI-FANG CHENG YEN-WEN WU KAO-LANG LIU RUOH-FANG YEN YAO-MING WU CHIUN HSU YU-TING CHANG KAI-YUAN TZEN HSIU-PO WANG |
公開日期: | 2011 | 卷: | 32 | 期: | 4 | 起(迄)頁: | 252-259 | 來源出版物: | Nuclear Medicine Communications | 摘要: | Background And Aim: Infiltrative hepatic lesions in conventional imaging modalities are a continuing diagnostic challenge in clinical practice, especially in an endemic area of viral hepatitis. The purpose of this study isto prospectively assess the role of F-fluoro-2-deoxy-D-glucose (FDG)-positron emission tomography/computed tomography (PET/CT) in indeterminate infiltrative hepatic lesions seen in conventional CT or magnetic resonance imaging (MRI). Methods: Dual-phase FDG-PET/CT was performed on35consecutive patients with indeterminate infiltrative hepatic lesions in CT or MRI. The variables analyzed included visual score and maximum standardized uptakevalue. Final diagnosis was histopathology orclinicalfollow-up for at least 12 months. Results: Malignancy was proven in 28 patients and there were benign strictures in seven patients. Sensitivity, specificity, and overall diagnostic accuracy of FDG-PET/CT using visual score were 85.7% (24/28), 71.4% (5/7), and 82.9% (29/35). Early and delayed maximum standardized uptake values were significantly higher in infiltrative hepatic malignancies than in benign lesions. Furthermore, PET/CT detected 13 unexpected distant metastatic foci notseen in other imaging studies. Thirteen patients (37.1%)had the plans of clinical treatment altered by FDG-PET/CT alone. Conclusion: FDG-PET/CT can help to clarify the diagnosis of indeterminate infiltrative hepatic lesions in CT or MRI. Inthis patient population, FDG-PET/CT may hold promisein the detection of unsuspected occult metastases, facilitating decision making and treatment planning. ? 2011 Wolters Kluwer Health | Lippincott Williams &Wilkins. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-79952445140&doi=10.1097%2fMNM.0b013e32834368bf&partnerID=40&md5=732ddea91feb2d1d0ccde65914fc0d47 https://scholars.lib.ntu.edu.tw/handle/123456789/457880 |
ISSN: | 0143-3636 | DOI: | 10.1097/MNM.0b013e32834368bf | SDG/關鍵字: | alpha fetoprotein; bilirubin; CA 19-9 antigen; fluorodeoxyglucose f 18; diagnostic agent; fluorodeoxyglucose f 18; radiopharmaceutical agent; adult; aged; article; bile duct carcinoma; bilirubin blood level; clinical article; computer assisted tomography; controlled clinical trial; diagnostic accuracy; diagnostic test accuracy study; diagnostic value; distant metastasis; drug uptake; false negative result; false positive result; feasibility study; female; follow up; hepatitis B; hepatitis C; histopathology; human; human tissue; liver cancer; liver cirrhosis; liver disease; liver metastasis; lymph node metastasis; male; mediastinum lymph node; nuclear magnetic resonance imaging; positron emission tomography; predictive value; primary sclerosing cholangitis; prospective study; protein blood level; receiver operating characteristic; sensitivity and specificity; spine metastasis; treatment planning; virus hepatitis; computer assisted emission tomography; computer assisted tomography; diagnostic imaging; differential diagnosis; endemic disease; liver tumor; methodology; middle aged; Taiwan; virus hepatitis; Adult; Aged; Aged, 80 and over; Diagnosis, Differential; Diagnostic Imaging; Endemic Diseases; Female; Fluorodeoxyglucose F18; Hepatitis, Viral, Human; Humans; Liver Neoplasms; Male; Middle Aged; Positron-Emission Tomography; Prospective Studies; Radiopharmaceuticals; Sensitivity and Specificity; Taiwan; Tomography, Emission-Computed; Tomography, X-Ray Computed |
顯示於: | 醫學系 |
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