https://scholars.lib.ntu.edu.tw/handle/123456789/457919
標題: | Liver transplantation for patients with hepatocellular carcinoma | 作者: | MING-CHIH HO YAO-MING WU REY-HENG HU Ko W.-J. PEI-MING YANG Lai M.-Y. Lin M.-H. Lin H.-Y. PO-HUANG LEE |
公開日期: | 2004 | 卷: | 36 | 期: | 8 | 起(迄)頁: | 2291-2292 | 來源出版物: | Transplantation Proceedings | 摘要: | Liver transplantation (LT) has been advocated as a salvage treatment for unresectable hepatocellular carcinoma (HCC). Selection criteria still need to be developed in Taiwan. The purpose of our study was to assess the clinical findings and outcome of cirrhotic patients with HCC undergoing liver transplantation. Our study consisted of 13 HCC patients who underwent liver transplantation during October 1996 to March 2003. The medical records and pathologic reports were analyzed retrospectively. Overall survival rates at 1 and 3 years were 86% and 61%, respectively. HCC recurrences occurred in three patients, one of whom is still alive with HCC recurrence 2 years after LT. The other two patients died of HCC recurrence 1 and 2 years after LT, respectively. Pretransplant α-fetoprotein (AFP) levels of >200 ng/mL were noted in all three patients with HCC recurrence. In contrast, only one of the ten patients without HCC recurrence had pretransplant AFP >200 ng/mL (P =. 003). Four patients did not meet Milan criteria, two of whom had HCC recurrence. However, the other two patients with microscopic vascular invasion survived and were free of HCC. The only one patient, who had histologic grade 4 HCC, died of recurrence, although his tumor was AJCC stage 1. High AFP level is a risk factor for HCC recurrence after LT. In addition to Milan criteria, histologic tumor grading should be considered in patient selection. Microscopic vascular invasion may not affect the outcome of the patients with early HCC. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-9244251046&doi=10.1016%2fj.transproceed.2004.08.098&partnerID=40&md5=41ee79615933bafbfe0906a7dba72e30 https://scholars.lib.ntu.edu.tw/handle/123456789/457919 |
ISSN: | 0041-1345 | DOI: | 10.1016/j.transproceed.2004.08.098 | SDG/關鍵字: | adult; cancer grading; cancer invasion; cancer recurrence; cancer risk; cancer survival; clinical article; conference paper; controlled study; disease severity; female; histology; human; liver cell carcinoma; liver cirrhosis; liver transplantation; male; patient selection; priority journal; risk factor; survival rate; treatment outcome; Carcinoma, Hepatocellular; Humans; Liver Cirrhosis; Liver Neoplasms; Liver Transplantation; Middle Aged; Postoperative Complications; Prevalence; Retrospective Studies |
顯示於: | 醫學系 |
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