https://scholars.lib.ntu.edu.tw/handle/123456789/458227
標題: | Role of lipocalin 2 and its complex with matrix metalloproteinase-9 in oral cancer | 作者: | Lin C.-W Tseng S.-W Yang S.-F Ko C.-P Lin C.-H LING-HUNG WEI Chien M.-H Hsieh Y.-S. |
關鍵字: | Lipocalin 2; Matrix metalloproteinase-9; Oral squamous cell carcinoma | 公開日期: | 2012 | 卷: | 18 | 期: | 8 | 起(迄)頁: | 734-740 | 來源出版物: | Oral Diseases | 摘要: | Objectives: Recent evidence demonstrated that lipocalin (LCN)2 is induced in many types of human cancer, while the detection of its complex with matrix metalloproteinase (MMP)-9 is correlated with the cancer disease status. We attempted to evaluate plasma expressions of LCN2, MMP-9, and their complex (LCN2/MMP-9) during the diagnostic work-up of patients with oral squamous cell carcinoma (OSCC) and investigated their correlations with disease progression. Methods: In total, 195 patients with OSCC and 81 healthy controls were recruited. Expression levels of LCN2, MMP-9, and LCN2/MMP-9 were determined with immunoenzymatic assays. Results: Patients with OSCC exhibited significantly higher levels of LCN2, MMP-9, and LCN2/MMP-9 compared with healthy controls (LCN2: P<0.001; MMP-9: P<0.001; LCN2/MMP-9: P<0.01). Plasma levels of LCN2, MMP-9, and LCN2/MMP-9 in patients with OSCC were significantly correlated with each other and were associated with more-advanced clinical stages (P<0.05) and/or a larger tumor size (P<0.05), but were not associated with positive lymph-node metastasis or distal metastasis. Conclusion: Our results suggest that plasma levels of LCN2 and the LCN2/MMP-9 complex may be useful in non-invasively monitoring OSCC progression, while supporting their potential role as biomarkers of oral cancer disease status. ? 2012 John Wiley & Sons A/S. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/458227 | ISSN: | 1354-523X | DOI: | 10.1111/j.1601-0825.2012.01938.x | SDG/關鍵字: | gelatinase B; neutrophil gelatinase associated lipocalin; adult; article; cancer growth; cancer staging; controlled study; correlational study; disease association; enzyme immunoassay; female; human; lymph node metastasis; major clinical study; male; mouth squamous cell carcinoma; predictive value; priority journal; protein analysis; protein blood level; protein expression; protein function; tumor volume; Acute-Phase Proteins; Areca; Carcinoma, Squamous Cell; Cell Differentiation; Disease Progression; Female; Humans; Lipocalins; Lymphatic Metastasis; Male; Matrix Metalloproteinase 9; Middle Aged; Mouth Neoplasms; Neoplasm Grading; Neoplasm Staging; Protein Binding; Proto-Oncogene Proteins; Smoking; Tumor Markers, Biological |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。