https://scholars.lib.ntu.edu.tw/handle/123456789/458529
Title: | The G-quadruplex fluorescent probe 3,6-bis(1-methyl-2-vinyl-pyridinium) carbazole diiodide as a biosensor for human cancers | Authors: | Tseng T.-Y. Chen W.-W. Chu I.-T. Wang C.-L. Chang C.-C. MEI-CHUN LIN PEI-JEN LOU Chang T.-C. |
Issue Date: | 2018 | Journal Volume: | 8 | Journal Issue: | 1 | Source: | Scientific Reports | Abstract: | Using time-gated fluorescence lifetime imaging microscopy, significantly more signals from 3,6-bis(1-methyl-2-vinyl-pyridinium) carbazole diiodide (o-BMVC) foci, characterized by the longer fluorescent decay time of o-BMVC, were detected in six types of cancer cells than in three types of normal cells. Accumulating evidence suggested that the o-BMVC foci are mainly the G-quadruplex foci. The large contrast in the number of o-BMVC foci can be considered as a common signature to distinguish cancer cells from normal cells. Further study of tissue biopsy showed that the o-BMVC test provides a high accuracy for clinical detection of head and neck cancers. ? 2018, The Author(s). |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/458529 | ISSN: | 2045-2322 | DOI: | 10.1038/s41598-018-34378-8 | SDG/Keyword: | 3,6-bis(1-methyl-4-vinylpyridium)carbazole diiodide; carbazole derivative; fluorescent dye; guanine quadruplex; pyridinium derivative; case control study; chemistry; fluorescence microscopy; genetic procedures; genetics; head and neck tumor; human; metabolism; mouth; pathology; procedures; tumor cell culture; Biosensing Techniques; Carbazoles; Case-Control Studies; Fluorescent Dyes; G-Quadruplexes; Head and Neck Neoplasms; Humans; Microscopy, Fluorescence; Mouth; Pyridinium Compounds; Tumor Cells, Cultured |
Appears in Collections: | 醫學院附設醫院 (臺大醫院) |
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