https://scholars.lib.ntu.edu.tw/handle/123456789/458529
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Tseng T.-Y. | en_US |
dc.contributor.author | Chen W.-W. | en_US |
dc.contributor.author | Chu I.-T. | en_US |
dc.contributor.author | Wang C.-L. | en_US |
dc.contributor.author | Chang C.-C. | en_US |
dc.contributor.author | MEI-CHUN LIN | en_US |
dc.contributor.author | PEI-JEN LOU | en_US |
dc.contributor.author | Chang T.-C. | en_US |
dc.creator | Chang T.-C.;Lou P.-J.;MEI-CHUN LIN;Chang C.-C.;Wang C.-L.;Chu I.-T.;Chen W.-W.;Tseng T.-Y. | - |
dc.date.accessioned | 2020-02-13T07:58:38Z | - |
dc.date.available | 2020-02-13T07:58:38Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/458529 | - |
dc.description.abstract | Using time-gated fluorescence lifetime imaging microscopy, significantly more signals from 3,6-bis(1-methyl-2-vinyl-pyridinium) carbazole diiodide (o-BMVC) foci, characterized by the longer fluorescent decay time of o-BMVC, were detected in six types of cancer cells than in three types of normal cells. Accumulating evidence suggested that the o-BMVC foci are mainly the G-quadruplex foci. The large contrast in the number of o-BMVC foci can be considered as a common signature to distinguish cancer cells from normal cells. Further study of tissue biopsy showed that the o-BMVC test provides a high accuracy for clinical detection of head and neck cancers. ? 2018, The Author(s). | - |
dc.relation.ispartof | Scientific Reports | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | 3,6-bis(1-methyl-4-vinylpyridium)carbazole diiodide; carbazole derivative; fluorescent dye; guanine quadruplex; pyridinium derivative; case control study; chemistry; fluorescence microscopy; genetic procedures; genetics; head and neck tumor; human; metabolism; mouth; pathology; procedures; tumor cell culture; Biosensing Techniques; Carbazoles; Case-Control Studies; Fluorescent Dyes; G-Quadruplexes; Head and Neck Neoplasms; Humans; Microscopy, Fluorescence; Mouth; Pyridinium Compounds; Tumor Cells, Cultured | - |
dc.title | The G-quadruplex fluorescent probe 3,6-bis(1-methyl-2-vinyl-pyridinium) carbazole diiodide as a biosensor for human cancers | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1038/s41598-018-34378-8 | - |
dc.identifier.pmid | 30382130 | - |
dc.identifier.scopus | 2-s2.0-85055780831 | - |
dc.relation.journalvolume | 8 | - |
dc.relation.journalissue | 1 | - |
item.openairetype | journal article | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Otolaryngology | - |
crisitem.author.dept | Otolaryngology-NTUH | - |
crisitem.author.dept | Otolaryngology | - |
crisitem.author.dept | Otolaryngology-NTUH | - |
crisitem.author.orcid | 0000-0003-1133-6741 | - |
crisitem.author.orcid | 0000-0002-3383-8593 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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