https://scholars.lib.ntu.edu.tw/handle/123456789/458564
標題: | Large cell neuroendocrine carcinoma of the endometrium: A case report and literature review | 作者: | YI-AN TU YU-LI CHEN Lin M.-C. CHI-AN CHEN WEN-FANG CHENG |
公開日期: | 2018 | 卷: | 57 | 期: | 1 | 起(迄)頁: | 144-149 | 來源出版物: | Taiwanese Journal of Obstetrics and Gynecology | 摘要: | Objective: To report a case and review published cases of large cell neuroendocrine carcinoma (LCNEC) of the endometrium. Case report: A 51-year-old female presented with postmenopausal bleeding and a palpable pelvic mass. An endometrial biopsy showed a malignant mixed Mullerian tumor (MMMT). Suboptimal debulking surgery was performed. The final pathology revealed stage IVB endometrial LCNEC. Post-operative adjuvant chemotherapy with cisplatin and etoposide was administered. Two months after discontinuing adjuvant chemotherapy, salvage chemotherapy with cisplatin and ifosfamide was administered due to tumor progression; however, obstructive ileus was noted 2 months later. A segmental small bowel resection and palliative colostomy were performed. She died secondary to a post-operative infection 8 days after the operation. Conclusion: Endometrial LCNEC is a rare but aggressive disease. If diagnosed, combined therapies, including staging surgery, following by adjuvant radiotherapy and chemotherapy, should be performed. ? 2018 |
URI: | 2-s2.0-85040563838 https://scholars.lib.ntu.edu.tw/handle/123456789/458564 |
ISSN: | 1028-4559 | DOI: | 10.1016/j.tjog.2017.12.025 | SDG/關鍵字: | CA 125 antigen; CD56 antigen; chromogranin; cisplatin; cytokeratin; ertapenem; estrogen receptor; etoposide; ifosfamide; meropenem; mesna; protein p53; synaptophysin; vimentin; antineoplastic agent; cisplatin; etoposide; abdominal discomfort; abdominal infection; abdominal tumor; adjuvant chemotherapy; adult; anorexia; Article; backache; cancer palliative therapy; cancer staging; carcinomatous peritonitis; case report; cause of death; clinical article; clinical evaluation; colostomy; computer assisted tomography; constipation; cytoreductive surgery; drug substitution; drug withdrawal; endometrioid carcinoma; endometrium biopsy; endometrium cancer; endometrium carcinoma; female; follow up; histopathology; human; human tissue; hydroureter; hysterectomy; ileus; immunohistochemistry; laboratory test; laparotomy; large cell neuroendocrine carcinoma; large cell neuroendocrine carcinoma of the endometrium; liver metastasis; lymphadenopathy; medical history; menopausal syndrome; middle aged; mixed Mullerian tumor; multiple organ failure; myometrium; nuclear magnetic resonance imaging; omentectomy; Papanicolaou test; paraaortic lymph node; patient referral; pelvic examination; pelvis tumor; postoperative care; postoperative infection; Pseudomonas; salpingooophorectomy; salvage therapy; small intestine resection; thorax radiography; time to treatment; transvaginal echography; tumor growth; tumor volume; vagina bleeding; carcinoma; endometrium; endometrium tumor; large cell carcinoma; multimodality cancer therapy; pathology; procedures; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Large Cell; Carcinoma, Neuroendocrine; Chemotherapy, Adjuvant; Cisplatin; Combined Modality Therapy; Endometrial Neoplasms; Endometrium; Etoposide; Female; Humans; Middle Aged; Salvage Therapy |
顯示於: | 醫學系 |
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