https://scholars.lib.ntu.edu.tw/handle/123456789/458566
標題: | Survival benefit of patients with early-stage ovarian carcinoma treated with paclitaxel chemotherapeutic regimens | 作者: | Chen C.-A. CHUN-JU CHIANG Chen Y.-Y. You S.-L. Hsieh S.-F. Tang C.-H. WEN-FANG CHENG |
公開日期: | 2018 | 卷: | 29 | 期: | 1 | 來源出版物: | Journal of Gynecologic Oncology | 摘要: | Objective: Adjuvant chemotherapy was introduced in patients with early-stage ovarian cancer (OC). The benefit of standard chemotherapeutic regimens including taxane has not been established. Methods: Patients with early-stage OC from the National Health Insurance Research database of Taiwan who received platinum plus cyclophosphamide (CP) or platinum plus paclitaxel (PT) for 3–6 cycles were recruited, and the disease-free survival (DFS) and overall survival (OS) were determined. Results: A total of 1,510 early-stage OC patients, including 841 who received CP regimen and 699 who received PT regimen, were included. The 2 groups had a similar estimated probability of 5-year DFS (PT vs. CP, 79.0% vs. 77.6%; p=0.410) and OS (84.6% vs. 84.3%; p=0.691). Patients >50 years of age who received the CP regimen had a lower 5-year DFS than the patients ?50 years of age who received the CP (p<0.001) or PT regimens (p=0.001). Additionally, patients >50 years of age who received the CP regimen had a worse 5-year OS compared with the other 3 groups (p=0.019) (p=0.179 for patients >50 years of age in the PT group; p=0.002 for patients ?50 years of age in the CP group; and p=0.061 for patients ?50 years of age in the PT group). Patients with the CP or PT regimen for 3–5 cycles had a similar 5-year DFS and OS compared to 6 cycles (p>0.050). Conclusion: Chemotherapeutic regimens with taxane could be recommended for early-stage OC patients >50 years of age. ? 2018. Asian Society of Gynecologic Oncology, Korean Society of Gynecologic Oncology. |
URI: | 2-s2.0-85036536930 https://scholars.lib.ntu.edu.tw/handle/123456789/458566 |
ISSN: | 2005-0380 | DOI: | 10.3802/jgo.2018.29.e16 | SDG/關鍵字: | cyclophosphamide; paclitaxel; antineoplastic agent; paclitaxel; adult; age distribution; Article; cancer adjuvant therapy; cancer staging; cohort analysis; controlled study; disease free survival; female; high risk patient; human; major clinical study; middle aged; multiple cycle treatment; ovary carcinoma; overall survival; probability; retrospective study; Taiwan; treatment duration; treatment outcome; adjuvant chemotherapy; aged; cancer staging; epidemiology; mortality; ovariectomy; ovary tumor; pathology; survival analysis; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Female; Humans; Middle Aged; Neoplasm Staging; Ovarian Neoplasms; Ovariectomy; Paclitaxel; Retrospective Studies; Survival Analysis; Taiwan |
顯示於: | 醫學系 |
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