https://scholars.lib.ntu.edu.tw/handle/123456789/458577
標題: | The prognostic impact of type 2 diabetes mellitus on early cervical cancer in Asia | 作者: | HUNG-YANG KUO ZHONG-ZHE LIN Kuo R. Shau W.-Y. Lai C.-L. Yang Y.-Y. YU-YUN SHAO CHIUN HSU WEN-FANG CHENG ANN-LII CHENG CHIH-HSIN YANG Lai M.-S. |
公開日期: | 2015 | 卷: | 20 | 期: | 9 | 起(迄)頁: | 1051-1057 | 來源出版物: | Oncologist | 摘要: | Background. Many studies have shown that type 2 diabetes mellitus (DM) increases the risk for several types of cancer but not cervical cancer (CC). Although DM and insulin-like growth factor 1 have preclinical and clinical implications for CC, less is known about the prognostic impact of DM on patients with early stage CC. Patients and Methods. We used the nationwide Taiwan Cancer Registry database to collect the characteristics of stage I-IIA cervical cancer patients diagnosed between 2004 and 2008. DM and other comorbidities were retrieved from the National Health Insurance database. Cervical cancer-specific survival (CSS) and overall survival (OS) times of patients according to DM status were estimated using the Kaplan-Meier method. We used a Cox proportional hazards model to calculate adjusted hazard ratios (HRs) for the effects of DM and other risk factors on mortality. Results. A total of 2,946 patients had primary stage I-IIA CC and received curative treatments, and 284 (9.6%) had DM.The 5-year CSS and OS rates for patients with DM were significantly lower than those without DM (CSS: 85.4% vs. 91.5%; OS: 73.9% vs. 87.9%). After adjusting for clinicopathologic variables and comorbidities, DM remained an independent unfavorable prognostic factor for CSS (adjusted HR: 1.46) and OS (adjusted HR: 1.55). Conclusion. In Asian patients with early cervical cancer, DM is an independent unfavorable prognostic factor influ-encing both OS and CSS, even after curative treatments. ? Alpha Med Press 2015. |
URI: | 2-s2.0-84940705024 https://scholars.lib.ntu.edu.tw/handle/123456789/458577 |
ISSN: | 1083-7159 | DOI: | 10.1634/theoncologist.2015-0111 | SDG/關鍵字: | somatomedin C; adult; age; aged; Article; cancer prognosis; cancer specific survival; comorbidity; controlled study; female; human; major clinical study; mortality; non insulin dependent diabetes mellitus; overall survival; priority journal; risk factor; Taiwan; uterine cervix cancer; Diabetes Mellitus, Type 2; early cancer diagnosis; male; metabolism; middle aged; pathology; prognosis; proportional hazards model; register; survival analysis; Uterine Cervical Neoplasms; very elderly; Adult; Aged; Aged, 80 and over; Diabetes Mellitus, Type 2; Early Detection of Cancer; Female; Humans; Male; Middle Aged; Prognosis; Proportional Hazards Models; Registries; Risk Factors; Survival Analysis; Taiwan; Uterine Cervical Neoplasms |
顯示於: | 醫學系 |
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