|Title:||Overexpression of CHI3L1 is associated with chemoresistance and poor outcome of epithelial ovarian carcinoma||Authors:||YING-CHENG CHIANG
|Issue Date:||2015||Journal Volume:||6||Journal Issue:||37||Start page/Pages:||39740-39755||Source:||Oncotarget||Abstract:||
We propose CHI3L1 as a prognostic biomarker for patients with epithelial ovarian carcinoma (EOC) and also suggest possible biological functions of CHI3L1. We measured CHI3L1 expression with quantitative real time-polymerase chain reaction (qRT-PCR) in 180 women with EOC and evaluated correlations between CHI3L1 expression, clinicopathological characteristics, and the outcomes of the patients. The expression of CHI3L1 was higher in cancerous tissues than in normal tissues. The expression of CHI3L1 was also higher in patients with a serous histological type, advanced stage, and chemoresistance. Patients with high CHI3L1 expression had a shorter progressionfree survival (p < 0.001)and overall survival (p < 0.001). Patients with high CHI3L1 expression also had a high risk of recurrence (p < 0.001)and death (p < 0.001). In vitro studies showed that CHI3L1 up-regulated the expression of anti-apoptotic Mcl-1 protein and hampered paclitaxel-induced apoptosis of ovarian cancer cells. These results suggest that CHI3L1 shows potential as a prognostic biomarker for EOC. CHI3L1 may promote chemoresistance via inhibition of drug-induced apoptosis by up-regulating Mcl-1.
|ISSN:||1949-2553||DOI:||10.18632/oncotarget.5469||SDG/Keyword:||chitinase; chitinase 3 like 1 protein; paclitaxel; protein mcl 1; unclassified drug; adipocytokine; CHI3L1 protein, human; chitinase 3 like protein 1; lectin; MCL1 protein, human; paclitaxel; protein mcl 1; tumor marker; adult; apoptosis; Article; cancer cell; cancer grading; cancer prognosis; cancer recurrence; cancer risk; cancer staging; CHI3L1 gene; controlled study; death; drug resistance; epithelial ovarian carcinoma; female; gene; gene expression; histopathology; human; in vitro study; major clinical study; ovary carcinoma; overall survival; progression free survival; quantitative analysis; real time polymerase chain reaction; treatment outcome; upregulation; aged; analysis of variance; disease free survival; drug effects; gene expression regulation; genetics; metabolism; middle aged; Neoplasms, Glandular and Epithelial; outcome assessment; Ovarian Neoplasms; procedures; prognosis; proportional hazards model; reverse transcription polymerase chain reaction; RNA interference; statistics and numerical data; tumor cell line; Western blotting; Adipokines; Adult; Aged; Analysis of Variance; Apoptosis; Biomarkers, Tumor; Blotting, Western; Cell Line, Tumor; Chitinase-3-Like Protein 1; Disease-Free Survival; Drug Resistance, Neoplasm; Female; Gene Expression Regulation, Neoplastic; Humans; Lectins; Middle Aged; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasms, Glandular and Epithelial; Outcome Assessment (Health Care); Ovarian Neoplasms; Paclitaxel; Prognosis; Proportional Hazards Models; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference
|Appears in Collections:||醫學系|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.