https://scholars.lib.ntu.edu.tw/handle/123456789/458632
Title: | High mesothelin correlates with chemoresistance and poor survival in epithelial ovarian carcinoma | Authors: | WEN-FANG CHENG Huang C.-Y. Chang M.-C. Hu Y.-H. YING-CHENG CHIANG YU-LI CHEN CHANG-YAO HSIEH CHI-AN CHEN |
Issue Date: | 2009 | Journal Volume: | 100 | Journal Issue: | 7 | Start page/Pages: | 1144-1153 | Source: | British Journal of Cancer | Abstract: | The objective of this paper is to investigate the mesothelin expression level to the clinicopathological features, chemoresponse, and to the outcome of patients with epithelial ovarian carcinoma (EOC). Mesothelin mRNA was detected by real-time quantitative reverse-transcription PCR in 139 EOC patients. Clinical characteristics, histopathological items, responses to chemotherapy, progression-free survival (PFS), and overall survival (OS) were recorded. Tumours with advanced stages had higher mesothelin than those with early stages. The chemoresistant patients showed significantly higher mesothelin than did chemosensitive patients (2.81 vs 0.43, P0.001), irrespective of optimal or suboptimal surgery in those with advanced stages. Highly expressed levels of mesothelin were an independent but poor prognostic factor in the PFS (2.03 (1.23-3.37) P0.006) and OS (3.72 (1.64-8.45), P0.002) of the 139 EOC patients in multivariate analysis. In addition, patients in advanced stages with highly expressed mesothelin also had significantly worse OS, regardless of whether they had undergone optimal (13.85 (1.76-125.60), P0.013) or suboptimal (4.47 (1.83-10.88), P0.001) debulking surgery in multivariate analysis. Out results provide new evidence that mesothelin expression is associated with chemoresistance and with shorter disease-free survival and worse OS of patients with EOC. ? 2009 Cancer Research UK. All rights reserved. |
URI: | 2-s2.0-63949085839 https://scholars.lib.ntu.edu.tw/handle/123456789/458632 |
ISSN: | 0007-0920 | DOI: | 10.1038/sj.bjc.6604964 | SDG/Keyword: | cyclophosphamide; mesothelin; messenger RNA; paclitaxel; platinum; adult; article; cancer chemotherapy; cancer growth; cancer resistance; cancer staging; cancer surgery; cancer survival; clinical feature; correlational study; cytoreductive surgery; disease free survival; female; human; human tissue; major clinical study; ovary carcinoma; overall survival; priority journal; prognosis; protein expression; real time polymerase chain reaction; treatment outcome; treatment response; Adult; Aged; CA-125 Antigen; Drug Resistance, Neoplasm; Female; Humans; Membrane Glycoproteins; Middle Aged; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger |
Appears in Collections: | 醫學系 |
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