https://scholars.lib.ntu.edu.tw/handle/123456789/458668
標題: | Human papillomavirus vaccine for cervical cancer: Where are we now? | 作者: | WEN-FANG CHENG | 關鍵字: | Cervical cancer; Human papillomavirus; Vaccine | 公開日期: | 2005 | 卷: | 44 | 期: | 3 | 起(迄)頁: | 232-241 | 來源出版物: | Taiwanese Journal of Obstetrics and Gynecology | 摘要: | Globally, cervical cancer is one of the most common cancers in women, representing up to 25% of all female cancers, and is the most common cancer in developing countries. It kills around 250,000 women every year worldwide and around 1,000 in Taiwan. Cervical cancer is largely preventable through screening programs to diagnose cervical lesions that may progress to invasive cancer. It has recently been definitively linked to genital human papillomavirus (HPV) infections. HPV fulfills the criteria for a carcinogenic agent defined by the International Agency for Research on Cancer. More than 200 types of HPV have been identified by DNA sequence data, and 85 HPV genotypes have been well characterized to date. HPV can infect the basal epithelial cells of the skin or inner tissue linings and is, accordingly, categorized as either cutaneous or mucosal. Genital HPV infections are now recognized as a major risk factor in at least 95% of cervical cancers. Thirty different HPV genotypes have been identified as causative of sexually transmitted diseases, most of which induce lesions in the cervix, vagina, vulva, penis, and anus. The main aim of this review is to evaluate the current literature regarding the relationship between HPV and cervical neoplasm, host immune responses to HPV, and the current status of preventive and therapeutic HPV vaccines. |
URI: | 2-s2.0-25144440523 https://scholars.lib.ntu.edu.tw/handle/123456789/458668 |
ISSN: | 1028-4559 | DOI: | 10.1016/S1028-4559(09)60145-5 | SDG/關鍵字: | cancer vaccine; virus vaccine; cancer prevention; cancer risk; cancer screening; cellular immunity; disease association; human; immune response; incidence; Papilloma virus; prevalence; review; uterine cervix cancer; virus infection |
顯示於: | 醫學系 |
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