https://scholars.lib.ntu.edu.tw/handle/123456789/460265
Title: | Hypoadiponectinemia: A useful marker of dyslipidemia in women with polycystic ovary syndrome | Authors: | Chang C.-Y MEI-JOU CHEN WEI-SHIUNG YANG Yeh C.-Y HONG-NERNG HO SHEE-UAN CHEN YU-SHIH YANG |
Issue Date: | 2012 | Journal Volume: | 51 | Journal Issue: | 4 | Start page/Pages: | 583-590 | Source: | Taiwanese Journal of Obstetrics and Gynecology | Abstract: | Objective: Adiponectin plays a role in obesity, lipid metabolism, and anti-inflammation. Women with polycystic ovary syndrome (PCOS) are also at risk for dyslipidemia. Therefore, we investigated the association between adiponectin levels and the lipid profile including high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TGs) in women with PCOS and contemplated what role adiponectin might play in dyslipidemia with PCOS. Materials and Methods: We recruited 118 young Taiwanese women with PCOS. The women enrolled were not taking any medication and those with other systemic diseases of nonovarian origin, which could have affected the hypothalamic-pituitary-ovarian axis, were excluded. The serum lipid profile, metabolic and hormonal parameters, and adiponectin were measured. The lipid profile and adiponectin were analyzed and adjusted for age, body mass index (BMI), homeostasis model assessment-insulin resistance (HOMA-IR), and sex hormone-binding globulin (SHBG). Results: In a simple linear regression, adiponectin was significantly inversely related to LDL-C and TGs, but positively related to HDL-C (all p < 0.001) after logarithmic transformation. In the multiple linear regression, adiponectin was significantly related to HDL-C (p < 0.001) independent of age, BMI, HOMA-IR, and SHBG after logarithmic transformation. Using a logistic regression, the odds ratio was 0.088 between the association of increased adiponectin and abnormal HDL-C (?50 mg/dL). Conclusions: We demonstrated that adiponectin is an independent biomarker that is positively and evidently related to HDL-C and TGs in women with PCOS. Hypoadiponectinemia may be a useful marker of dyslipidemia in women with PCOS. ? 2012. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/460265 | ISSN: | 1028-4559 | DOI: | 10.1016/j.tjog.2012.09.014 | SDG/Keyword: | adiponectin; cholesterol; estradiol; follitropin; glucose; high density lipoprotein cholesterol; insulin; low density lipoprotein cholesterol; luteinizing hormone; prasterone sulfate; sex hormone binding globulin; testosterone; triacylglycerol; adolescent; adult; age; article; body mass; cholesterol blood level; clinical assessment tool; diet restriction; dyslipidemia; estradiol blood level; female; follitropin blood level; glucose blood level; Homeostasis Model Assessment Insulin Resistance; human; hypoadiponectinemia; insulin blood level; luteinizing hormone blood level; major clinical study; metabolic parameters; ovary polycystic disease; protein blood level; testosterone blood level; triacylglycerol blood level; Adiponectin; Adolescent; Adult; Biological Markers; Body Mass Index; Cholesterol, HDL; Cholesterol, LDL; Dyslipidemias; Female; Homeostasis; Humans; Insulin Resistance; Linear Models; Logistic Models; Metabolism, Inborn Errors; Models, Biological; Odds Ratio; Polycystic Ovary Syndrome; Sex Hormone-Binding Globulin; Taiwan; Triglycerides; Young Adult |
Appears in Collections: | 醫學系 |
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