https://scholars.lib.ntu.edu.tw/handle/123456789/460890
標題: | Insulin-like growth factor binding protein-3 (IGFBP-3) acts as an invasion-metastasis suppressor in ovarian endometrioid carcinoma | 作者: | PAO-LING TORNG Lee Y.-C.G Huang C.-Y.F Ye J.-H Lin Y.-S Chu Y.-W Huang S.-C Cohen P Wu C.-W CHIN-TARNG LIN |
公開日期: | 2008 | 卷: | 27 | 期: | 15 | 起(迄)頁: | 2137-2147 | 來源出版物: | Oncogene | 摘要: | Metastasis and invasion occur in the majority of epithelial ovarian carcinoma at diagnosis. To delineate the molecular signature in ovarian cancer invasion, we established and characterized a human ovarian endometrioid carcinoma (EC) cell line OVTW59-P0 and its invasion-related sublines (P1-P4, in the order of increasing invasive activity). P4 showed faster migration and larger xenograft formation with metastasis than P0. By microarray analysis of different gene expression among P0-P4 sublines, one group of gene was found negatively correlated with cancer invasion. Among these genes, IGFBP-3 was identified as one of the most remarkably suppressed gene that showed lower gene expression in P4 than P0. Re-expression of IGFBP-3 in P4 effectively inhibited cell migration, invasion and metastasis, but did not affect cell proliferation. In 35 patients with EC tumors, low IGFBP-3 expression correlated clinically with higher tumor grade, advanced stage and poor survival. Our results provide evidence and indicate that IGFBP-3 plays an important role as an invasion-metastasis suppressor in ovarian EC. ? 2008 Nature Publishing Group All rights reserved. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/460890 | ISSN: | 0950-9232 | DOI: | 10.1038/sj.onc.1210864 | SDG/關鍵字: | somatomedin binding protein 3; adult; advanced cancer; article; cancer cell culture; cancer grading; cancer inhibition; cancer invasion; cancer survival; cell proliferation; clinical article; endometrioid carcinoma; female; gene expression; human; human cell; human tissue; microarray analysis; ovary metastasis; priority journal; protein function; survival rate; survival time; tumor gene; tumor suppressor gene; xenograft; Adult; Aged; Carcinoma, Endometrioid; Cell Culture Techniques; Cell Line, Tumor; Cell Movement; Cluster Analysis; Cytogenetic Analysis; Disease Progression; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Humans; Insulin-Like Growth Factor Binding Protein 3; Middle Aged; Neoplasm Invasiveness; Neoplasm Metastasis; Oligonucleotide Array Sequence Analysis; Ovarian Neoplasms; Prognosis; Survival Analysis |
顯示於: | 醫學系 |
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