https://scholars.lib.ntu.edu.tw/handle/123456789/461753
標題: | Human cationic trypsinogen but not serine peptidase inhibitor, Kazal type 1 variants increase the risk of type 1 autoimmune pancreatitis | 作者: | MING-CHU CHANG I-SHIOW JAN PO-CHIN LIANG YUNG-MING JENG CHING-YAO YANG YU-WEN TIEN Wong J.-M. YU-TING CHANG |
公開日期: | 2014 | 出版社: | Blackwell Publishing | 卷: | 29 | 期: | 12 | 起(迄)頁: | 2038-2042 | 來源出版物: | Journal of Gastroenterology and Hepatology (Australia) | 摘要: | Background and Aim: Autoimmune pancreatitis (AIP) is a distinct disease entity. Whether the genes involved in pancreatic acinar cell injury, cationic trypsinogen gene (protease, serine, 1 [trypsin 1] [PRSS1]) and the pancreatic secretory trypsin inhibitor gene (serine peptidase inhibitor, Kazal type 1 [SPINK1]), are associated with AIP remains to be explored. Methods: Genetic analyses of PRSS1 variants (exon 2 and 3) and SPINK1 variants (exon 1, 2, and 3) including the intronic areas in 118 patients with AIP and 200 control subjects were performed by direct DNA sequencing. Clinical features including imaging, histology, serology, response to steroid, and extra-pancreatic organ involvement in AIP patients with and without variants were compared. Results: A total of 19 PRSS1 variants and one SPINK1 variant were identified in 20 (16.9%) out of 118 AIP patients. They included one K92N, nine R116C, seven T137M, one C139S, and one C139F of PRSS1 and one 2(IVS3+2) of SPINK1. No PRSS1 or SPINK1 variant was identified in the control group. Patients with PRSS1 variants had an increased risk of AIP with odds ratio 22.37 (95% confidence interval: 2.96-168.8, P=0.003) and higher frequency of serum IgG4 above 280mg/dL. Using immunosuppressive agent and PRSS1 variant were predictors of less disease relapse in univariate analysis. Presence of PRSS1 variants was the only negative predictor for disease relapse in multivariate analysis. Conclusions: We found a significantly higher frequency of PRSS1 variants in AIP patients than in geographically and ethnically matched control subjects. PRSS1 variants are associated with less disease relapse in AIP. ? 2014 Wiley Publishing Asia Pty Ltd and Journal of Gastroenterology and Hepatology Foundation. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84931327679&doi=10.1111%2fjgh.12649&partnerID=40&md5=0f3b1cd3ded39edc34576f37d65c1c6f https://scholars.lib.ntu.edu.tw/handle/123456789/461753 |
ISSN: | 0815-9319 | DOI: | 10.1111/jgh.12649 | SDG/關鍵字: | DNA; immunoglobulin G4; immunosuppressive agent; serine proteinase; spink1 protein; steroid; trypsin; trypsin 1; trypsinogen; unclassified drug; carrier protein; PRSS1 protein, human; SPINK1 protein, human; trypsin; adult; aged; Article; autoimmune pancreatitis; clinical feature; confidence interval; controlled study; diagnostic imaging; diagnostic test accuracy study; DNA sequence; exon; female; gene expression; genetic analysis; genetic variability; hepatitis; histopathology; human; immunoglobulin blood level; immunosuppressive treatment; interstitial nephritis; major clinical study; male; middle aged; multivariate analysis; pancreas resection; plasma cell granuloma; predictive value; predictor variable; priority journal; relapse; risk factor; serology; serum; sialoadenitis; steroid therapy; treatment response; univariate analysis; autoimmune disease; genetics; pancreatitis; risk; Adult; Autoimmune Diseases; Carrier Proteins; Exons; Female; Genetic Variation; Humans; Male; Middle Aged; Pancreatitis; Risk; Trypsin |
顯示於: | 醫學系 |
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