https://scholars.lib.ntu.edu.tw/handle/123456789/461857
標題: | Hepatitis B and C viruses are not risks for pancreatic adenocarcinoma | 作者: | MING-CHU CHANG CHIEN-HUNG CHEN JA-DER LIANG YU-WEN TIEN CHIUN HSU Wong J.-M. YU-TING CHANG |
公開日期: | 2014 | 出版社: | WJG Press | 卷: | 20 | 期: | 17 | 起(迄)頁: | 5060-5065 | 來源出版物: | World Journal of Gastroenterology | 摘要: | Aim: To investigate whether hepatitis B virus (HBV) and hepatitis C virus (HCV) increase risk of pancreatic ductal adenocarcinoma (PDAC). Methods: We recruited 585 patients with cytological and/or pathologically confirmed PDAC in National Taiwan University Hospital from September 2000 to September 2013, and 1716 age-, sex-, and race-matched controls who received a screening program in a community located in Northern Taiwan. Blood samples were tested for the presence of HCV antibodies (anti-HCV), HBV surface antigen (HBsAg), antibodies against HBsAg (anti-HBs), and hepatitis B core antigen (anti-HBc) in all cases and controls. The odds ratio (OR) of PDAC was estimated by logistic regression analysis with adjustment diabetes mellitus (DM) and smoking. Results: HBsAg was positive in 73 cases (12.5%) and 213 controls (12.4%). Anti-HCV was positive in 22 cases (3.8%) and 45 controls (2.6%). Anti-HBs was positive in 338 cases (57.8%) and 1047 controls (61.0%). The estimated ORs of PDAC in multivariate analysis were as follows: DM, 2.08 (95%CI: 1.56-2.76, P < 0.001), smoking, 1.36 (95%CI: 1.02-1.80, P = 0.035), HBsAg+/anti-HBc+/anti-HBs-, 0.89 (95%CI: 0.89-1.68, P = 0.219), HBsAg-/anti-HBc+/anti-HBs+, 1.03 (95%CI: 0.84-1.25, P = 0.802). Conclusion: HBV and HCV infection are not associated with risk of PDCA after adjustment for age, sex, DM and smoking, which were independent risk factors of PDAC. ? 2014 Baishideng Publishing Group Co., Limited. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84899872090&doi=10.3748%2fwjg.v20.i17.5060&partnerID=40&md5=4e80ecfc23add8460b59220b56933e36 https://scholars.lib.ntu.edu.tw/handle/123456789/461857 |
ISSN: | 1007-9327 | DOI: | 10.3748/wjg.v20.i17.5060 | SDG/關鍵字: | hepatitis B core antibody; hepatitis B surface antibody; hepatitis B surface antigen; hepatitis C antibody; biological marker; hepatitis B antibody; hepatitis B core antigen; hepatitis B surface antigen; hepatitis C antibody; adult; alanine aminotransferase blood level; article; aspartate aminotransferase blood level; cancer risk; case control study; controlled study; female; Hepatitis B virus; Hepatitis C virus; human; major clinical study; male; nonhuman; pancreas adenocarcinoma; adverse effects; age; aged; blood; Carcinoma, Pancreatic Ductal; chi square distribution; diabetes mellitus; Hepacivirus; hepatitis B; Hepatitis B virus; hepatitis C; immunology; middle aged; multivariate analysis; Pancreatic Neoplasms; pathogenicity; retrospective study; risk; risk assessment; risk factor; sex difference; smoking; statistical model; Taiwan; virology; Age Factors; Aged; Biological Markers; Carcinoma, Pancreatic Ductal; Chi-Square Distribution; Diabetes Mellitus; Female; Hepacivirus; Hepatitis B; Hepatitis B Antibodies; Hepatitis B Core Antigens; Hepatitis B Surface Antigens; Hepatitis B virus; Hepatitis C; Hepatitis C Antibodies; Humans; Logistic Models; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Pancreatic Neoplasms; Retrospective Studies; Risk Assessment; Risk Factors; Sex Factors; Smoking; Taiwan |
顯示於: | 醫學系 |
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