https://scholars.lib.ntu.edu.tw/handle/123456789/461861
標題: | Nuclear expression of glioma-associated oncogene homolog 1 and nuclear factor-κb is associated with a poor prognosis of pancreatic cancer | 作者: | SHIH-HUNG YANG CHIH-HUNG HSU JEN-CHIEH LEE YU-WEN TIEN SUNG-HSIN KUO ANN-LII CHENG |
公開日期: | 2013 | 卷: | 85 | 期: | 2 | 起(迄)頁: | 86-94 | 來源出版物: | Oncology (Switzerland) | 摘要: | Objective: We investigated the association of the hedgehog pathway with nuclear factor (NF)-κB and clinical outcomes in pancreatic cancer patients. Methods: We analyzed tissue samples for the expression of NF-κB (RelA/p65), sonic hedgehog (Shh) and glioma-associated oncogene homolog 1 (Gli1) by immunohistochemistry and investigated their expression in association with clinical outcomes. Results: Eighty-one patients with pancreatic cancer were investigated. Expression of Shh and nuclear expression of Gli1 and NF-κB were found in 63 of 66 (96%), 28 of 68 (41%) and 22 of 68 cases (32%), respectively. Nuclear Gli1 expression was closely associated with nuclear expression of NF-κB (p < 0.001). Patients with nuclear Gli1 had significantly worse prognoses than those without (median survival 7.9 vs. 13.9 months; p = 0.009). Similarly, patients with nuclear expression of NF-κB had shorter overall survival than those with negative or cytoplasmic expression of NF-κB (median survival 5.5 vs. 13.9 months; p < 0.001). Shh expression had no prognostic significance. In the multivariate analysis, NF-κB nuclear expression was closely associated with unfavorable overall survival (p = 0.02). Conclusion: Our results indicate that nuclear expression of Gli1 or NF-κB is a strong predictor of poor prognosis in pancreatic cancer. Additional investigation of the biologic significance of this association is warranted. ? 2013 S. Karger AG, Basel. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84880182986&doi=10.1159%2f000353452&partnerID=40&md5=651b1f421f69cbd80fd5fff75072d6fd https://scholars.lib.ntu.edu.tw/handle/123456789/461861 |
ISSN: | 0030-2414 | DOI: | 10.1159/000353452 | SDG/關鍵字: | bevacizumab; CA 19-9 antigen; carcinoembryonic antigen; cetuximab; erlotinib; fluorouracil; gemcitabine; immunoglobulin enhancer binding protein; sonic hedgehog protein; transcription factor Gli1; sonic hedgehog protein; transcription factor RelA; adult; advanced cancer; aged; article; cancer prognosis; cancer radiotherapy; cancer surgery; cancer survival; cell nucleus; cytoplasm; disease association; distant metastasis; female; human; human tissue; immunohistochemistry; liver metastasis; major clinical study; male; medical record review; overall survival; pancreas cancer; priority journal; protein expression; retrospective study; treatment outcome; Article; cancer patient; cancer tissue; outcome assessment; pancreas cancer; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Carcinoma, Pancreatic Ductal; Cell Nucleus; Deoxycytidine; Female; Hedgehog Proteins; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Multivariate Analysis; Pancreatic Neoplasms; Prognosis; Transcription Factor RelA; Transcription Factors; Treatment Outcome |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。