https://scholars.lib.ntu.edu.tw/handle/123456789/462093
標題: | Open, randomized, comparative study of efficacy and safety between Haemopressin® and Glypressin® in treating acute esophageal varices hemorrhage | 作者: | REY-HENG HU PO-HUANG LEE |
公開日期: | 2008 | 卷: | 55 | 期: | 82-83 | 起(迄)頁: | 448-452 | 來源出版物: | Hepato-Gastroenterology | 摘要: | Background/Aims: Hemorrhage from esophageal varices is a major consequence of liver cirrhosis. Pharmacological treatment can be started immediately by an internist to arrest acute esophageal variceal hemorrhage (EVH). Terlipressin is easy to administer and effective in treating acute EVH, with or without adjuvant endoscopic sclerotherapy, and in reducing mortality in these patients. Due to these potentials, a phase IV bioequivalence study was conducted to compare a new brand of terlipressin (Haemopressin?: contains 1mg tri-glycyllysin- vasopressin acetate) with one that is currently available in the market (Glypressin?). Methodology: All cirrhotic patients with acute EVH were randomized to receive Haemopressin? (n=19) or Glypressin? (n=22) 2mg i.v. immediately followed by 1mg. i.v. q4h for 5 days. Results: The demographics were similar between H-group and G-group. Successful control of acute bleeding within 24 hours was no different between the 2 groups (18/19 vs. 19/22). Failure to control bleeding within 5 days of drug administration was also no different between the 2 groups (4/19 vs. 6/22). Rebleeding events, the requirement for blood transfusions and rescued treatment were also comparative between the 2 groups. Half of the patients in either group had mild, temporary and self-limited side effects. Conclusions: The study confirms that administration of terlipressin, by either Haemopressin? or Glypressin?, is generally safe and indeed highly effective in the treatment of acute EVH. ? H.G.E. Update Medical Publishing S.A. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-44349138799&partnerID=40&md5=200132b2fcb19a5e5828a4da3a471283 https://scholars.lib.ntu.edu.tw/handle/123456789/462093 |
ISSN: | 0172-6390 | SDG/關鍵字: | haemopressin; terlipressin; vasopressin derivative; abdominal pain; adult; article; blood transfusion; bradycardia; cancer patient; clinical article; clinical trial; controlled clinical trial; demography; drug efficacy; drug safety; esophagus varices bleeding; female; headache; heart arrhythmia; human; hypertension; hyponatremia; liver cirrhosis; male; priority journal; randomized controlled trial; thorax pain; Acute Disease; Esophageal and Gastric Varices; Female; Gastrointestinal Hemorrhage; Hemoglobins; Humans; Lysine Vasopressin; Male; Middle Aged; Peptide Fragments; Vasoconstrictor Agents |
顯示於: | 醫學系 |
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