https://scholars.lib.ntu.edu.tw/handle/123456789/462478
標題: | Comparison of childhood hepatic malignancies in a hepatitis B hyper-endemic area | 作者: | Chen J.-C. Chang M.-L. Lin J.-N. HONG-SHIEE LAI Chen C.-C. Chen W.-J. Hung W.-T. |
關鍵字: | Chemotherapy; Children; Hepatitis B; Hepatoblastoma; Hepatocellular carcinoma | 公開日期: | 2005 | 出版社: | WJG Press | 卷: | 11 | 期: | 34 | 起(迄)頁: | 5289-5294 | 來源出版物: | World Journal of Gastroenterology | 摘要: | Aim: To examine the differences of clinical behaviors between hepatocellular carcinomas (HCC) and hepatoblastomas (HB) in children. Methods: From 1979 to 1997, we collected 73 HCC and 54 HB from two major medical centers in Taiwan. Demographic, laboratory and radiological data, and survival curves were statistically compared. Results: HCC clinically differed from HB in mean age (10.6 vs 2.5 years; P<0.001), status of hepatitis B infection (56/56 vs 4/35, P<0.001) and accompanying liver cirrhosis (26/40 vs 0/30, P<0.001), portal vein thrombi (22/56 vs 5/38, P = 0.006) and para-aortic lymphadenopathy (10/56 vs 1/38, P = 0.026). Due to a higher recurrence rate (7/12 vs 2/13, P = 0.041), stage I HCC compared poorly in survivals with stage I HB (P = 0.0183). Chemotherapy could only benefit HB as evidenced by 66.7% of resectability conversion and improve survivals for advanced HB, even with unsuccessful conversion. The survival difference between stage I HB and advanced HB with delayed complete resection was of borderline insignificance (P = 0.0507). Conclusion: HCC and HB were preliminarily distinguishable by some clinical clues. Delayed resection after chemotherapy was only possible for HB. However, further studies are needed to strengthen our observation that appropriate reliance upon chemotherapy to subsequently resect advanced HB could achieve the comparable survival to that of stage I HB. ? 2005 The WJG Press and Elsevier Inc. All rights reserved. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-26244446827&doi=10.3748%2fwjg.v11.i34.5289&partnerID=40&md5=8eb5674d9c93f3bb963ccaea4e59617b https://scholars.lib.ntu.edu.tw/handle/123456789/462478 |
ISSN: | 1007-9327 | DOI: | 10.3748/wjg.v11.i34.5289 | SDG/關鍵字: | carboplatin; cisplatin; cyclophosphamide; doxorubicin; epirubicin; fluorouracil; vincristine; age distribution; article; cancer recurrence; cancer staging; cancer survival; child; childhood cancer; comparative study; controlled study; demography; disease activity; endemic disease; female; health care facility; hepatitis B; hepatoblastoma; human; laboratory test; liver cancer; liver cell carcinoma; liver cirrhosis; liver resection; lymphadenopathy; major clinical study; male; paraaortic lymph node; portal vein thrombosis; radiodiagnosis; statistical analysis; survival rate; Taiwan |
顯示於: | 醫學系 |
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