https://scholars.lib.ntu.edu.tw/handle/123456789/463693
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Tan E.K | en_US |
dc.contributor.author | Lu C.S | en_US |
dc.contributor.author | Peng R | en_US |
dc.contributor.author | Teo Y.Y | en_US |
dc.contributor.author | Wu-Chou Y.H | en_US |
dc.contributor.author | Chen R.S | en_US |
dc.contributor.author | Weng Y.H | en_US |
dc.contributor.author | Chen C.M | en_US |
dc.contributor.author | Fung H.C | en_US |
dc.contributor.author | Tan L.C | en_US |
dc.contributor.author | Zhang Z.J | en_US |
dc.contributor.author | An X.K | en_US |
dc.contributor.author | Lee-Chen G.J | en_US |
dc.contributor.author | Lee M.C | en_US |
dc.contributor.author | Fook-Chong S | en_US |
dc.contributor.author | Burgunder J.M | en_US |
dc.contributor.author | RUEY-MEEI WU | en_US |
dc.contributor.author | Wu Y.R. | en_US |
dc.creator | Wu Y.R.;RUEY-MEEI WU;Burgunder J.M;Fook-Chong S;Lee M.C;Lee-Chen G.J;An X.K;Zhang Z.J;Tan L.C;Fung H.C;Chen C.M;Weng Y.H;Chen R.S;Wu-Chou Y.H;Teo Y.Y;Peng R;Lu C.S;Tan E.K | - |
dc.date.accessioned | 2020-02-25T08:01:33Z | - |
dc.date.available | 2020-02-25T08:01:33Z | - |
dc.date.issued | 2010 | - |
dc.identifier.issn | 0197-4580 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/463693 | - |
dc.description.abstract | The inverse association of the functional ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y variant with Parkinson's disease (PD) among Caucasian populations has been debated. We conducted a large-scale analysis to investigate the age-of-onset effect of the UCHL1 variant in PD among ethnic Chinese. Individual data sets from 5 centers comprising a total of 4088 study subjects were analyzed. In the univariate analysis, only data from 1 center showed a trend towards a protective effect among young subjects. However, in the combined analysis, no significant association between the UCHL1 variant and PD was detected (A allele frequency 0.531 vs. 0.528, p=0.87, OR 1.01, 95% CI 0.92-1.1). Among subjects less than 60 years old, the OR is 0.99 (95% CI 0.84-1.16, p=0.88). A multivariate logistic regression analysis showed that family history, UCHL1 variant and the interaction of UCHL1 variant and age at onset (p=0.816) were not significantly associated with PD. ? 2008 Elsevier Inc. | - |
dc.relation.ispartof | Neurobiology of Aging | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | ubiquitin carboxy terminal hydrolase L1; ubiquitin thiolesterase; unclassified drug; adolescent; adult; aged; article; Caucasian; Chinese; controlled study; dimerization; ethnicity; gene frequency; genetic analysis; genetic association; genetic linkage; genetic polymorphism; genetic variability; human; logistic regression analysis; major clinical study; Parkinson disease; priority journal; protein protein interaction; Adolescent; Adult; Age of Onset; Aged; Aged, 80 and over; Asian Continental Ancestry Group; Female; Genetic Association Studies; Genetic Variation; Humans; Male; Middle Aged; Parkinson Disease; Singapore; Taiwan; Ubiquitin Thiolesterase; Ubiquitination; Young Adult | - |
dc.title | Analysis of the UCHL1 genetic variant in Parkinson's disease among Chinese | en_US |
dc.type | journal article | en |
dc.identifier.doi | 10.1016/j.neurobiolaging.2008.11.008 | - |
dc.identifier.pmid | 19329225 | - |
dc.identifier.scopus | 2-s2.0-78650174666 | - |
dc.relation.pages | 2194-2196 | - |
dc.relation.journalvolume | 31 | - |
dc.relation.journalissue | 12 | - |
item.fulltext | no fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_6501 | - |
item.cerifentitytype | Publications | - |
item.openairetype | journal article | - |
item.grantfulltext | none | - |
crisitem.author.dept | Neurology-NTUH | - |
crisitem.author.dept | Brain and Mind Sciences | - |
crisitem.author.dept | Neurology | - |
crisitem.author.dept | The Clinical Center for Neuroscience and Behavior | - |
crisitem.author.dept | Psychology | - |
crisitem.author.orcid | 0000-0002-4947-5467 | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Science | - |
顯示於: | 醫學系 |
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