https://scholars.lib.ntu.edu.tw/handle/123456789/463715
標題: | Analysis of Lrrk2 R1628P as a risk factor for Parkinson's disease | 作者: | Ross O.A Wu Y.-R Lee M.-C Funayama M Chen M.-L Soto A.I Mata I.F Lee-Chen G.-J Chiung M.C Tang M Zhao Y Hattori N Farrer M.J Tan E.-K RUEY-MEEI WU |
公開日期: | 2008 | 卷: | 64 | 期: | 1 | 起(迄)頁: | 88-92 | 來源出版物: | Annals of Neurology | 摘要: | Common genetic variants that increase the risk for Parkinson's disease may differentiate patient subgroups and influence future individualized therapeutic strategies. Herein we show evidence for leucine-rich repeat kinase 2 (LRRK2) c.4883G>C (R1628P) as a risk factor in ethnic Chinese populations. A study of 1,986 individuals from 3 independent centers in Taiwan and Singapore demonstrates that Lrrk2 R1628P increases risk for Parkinson's disease (odds ratio, 1.84; 95% confidence interval, 1.20-2.83; p = 0.006). Haplotype analysis suggests an ancestral founder for carriers approximately 2,500 years ago. These findings support the importance of LKRK2 variants in sporadic Parkinson's disease. ? 2008 American Neurological Association. Published by Wiley-Liss, Inc., through Wiley Subscription Services. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/463715 | ISSN: | 0364-5134 | DOI: | 10.1002/ana.21405 | SDG/關鍵字: | leucine rich repeat kinase 2; adult; article; Chinese; controlled study; genetic risk; genetic variability; haplotype; human; major clinical study; Parkinson disease; priority journal; risk factor; Singapore; Taiwan; Asian Continental Ancestry Group; DNA Mutational Analysis; Female; Founder Effect; Gene Frequency; Genetic Markers; Genetic Predisposition to Disease; Genetic Screening; Genotype; Humans; Male; Middle Aged; Mutation; Parkinson Disease; Polymorphism, Genetic; Protein-Serine-Threonine Kinases; Singapore; Taiwan |
顯示於: | 醫學系 |
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