https://scholars.lib.ntu.edu.tw/handle/123456789/463737
標題: | The COMT L allele modifies the association between MAOB polymorphism and PD in Taiwanese | 作者: | Kai Hsiang Stanley Chen RUEY-MEEI WU Cheng C.W Lu S.L Shan D.E YUNN-FANG HO Chern H.D. |
公開日期: | 13-二月-2001 | 卷: | 56 | 期: | 3 | 起(迄)頁: | 375 | 來源出版物: | Neurology | 摘要: | Objective: Reports suggest that catechol-O-methyltransferase (COMTL/L) (Val158/Met) and monoamine oxidase B (MAOB) intron 13 genotype polymorphism is associated with PD. To understand the ethnicity-specific effects of genetic polymorphism, we performed a case-control study of the association between PD susceptibility and polymorphism of MAOB and COMT, both separately and in combination, in Taiwanese. Methods: Two hundred twenty-four patients with PD and 197 controls, matched for age, sex, and birthplace, were recruited. MAOB and COMT polymorphism genotyping was performed by using PCR-based restriction fragment length polymorphism (RFLP) analyses. X2, OR, and Fisher's exact tests were used to compare differences in allelic frequencies and genotypes. Results: The MAOB G genotype (G in men and G/G in women) was associated with a 2.07-fold increased relative risk of PD. COMT polymorphism, considered alone, showed no correlation with PD risk; however, a significant synergistic enhancement was found in PD patients harboring both the COMTL and MAOB G genotypes. Conclusions: These results suggest that, in Taiwanese, PD risk is associated with MAOB G intron 13 polymorphism, and this association is augmented in the presence of the COMTL genotype, indicating an interaction of these two dopamine-metabolizing enzymes in the pathogenesis of sporadic PD. However, the relatively low frequencies of these combined genotypes in our study necessitates confirmation with a larger sample size. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/463737 | ISSN: | 0028-3878 | DOI: | 10.1212/WNL.56.3.375 | SDG/關鍵字: | amine oxidase (flavin containing) isoenzyme B; catechol methyltransferase; dopamine; methionine; valine; adult; aged; article; case control study; controlled study; dopamine metabolism; ethnic difference; female; gene frequency; genetic analysis; genetic polymorphism; genetic susceptibility; genotype; human; intron; major clinical study; male; Parkinson disease; pathogenesis; polymerase chain reaction; priority journal; restriction fragment length polymorphism; risk assessment; Taiwan |
顯示於: | 醫學系 |
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