https://scholars.lib.ntu.edu.tw/handle/123456789/463951
標題: | In vitro characterization of magnetic electrospun IDA-grafted chitosan nanofiber composite for hyperthermic tumor cell treatment | 作者: | Lin, T.-C. Lin, F.-H. Lin, J.-C. Lin, Feng-Huei |
關鍵字: | cancer treatment; chitosan; hyperthermia; magnetic nanofibers composite; magnetic nanoparticles | 公開日期: | 2013 | 卷: | 24 | 期: | 9 | 起(迄)頁: | 1152-1163 | 來源出版物: | Journal of Biomaterials Science, Polymer Edition | 摘要: | Magnetic nanoparticles were the thermoseeds under an alternating magnetic field and can be used to produce highly localized hyperthermia effect on deep-seated tumor. Nevertheless, effective and precisive delivery of nanoparticles to the treatment-intended site remains a challenge. In this study, Fe3O4 nanoparticles were incorporated onto the crosslinked electrospun chitosan nanofibers using chemical co-precipitation from the Fe ions adsorbed. Such magnetic nanoparticle-nanofiber composites could be delivered to the treatment site precisely by surgical or endoscopic method. Iminodiacetic acid (IDA) functionality was grafted onto the chitosan with an aim to increase the amount of magnetic nanoparticles formed in the electrospun magnetic nanofiber composite. The morphology, crystalline phase as well as the magnetism characteristic of the magnetic electrospun nanofiber matrixes, was analyzed. Results have indicated that, with the incorporation of IDA functionality, more magnetic nanoparticles were formed in the electrospun chitosan nanofiber matrix. In addition, the magnetic IDA-grafted chitosan nanofiber composite can effectively reduced the tumor cell proliferation under the application of magnetic field. This finding suggested the magnetic electrospun chitosan nanofiber composite can be of potential for hyperthermia treatment. ? 2013 Copyright Taylor and Francis Group, LLC. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/463951 | DOI: | 10.1080/09205063.2012.743061 | SDG/關鍵字: | Alternating magnetic field; Chemical co-precipitation; Electrospun nanofibers; hyperthermia; Hyperthermia treatments; Magnetic nano-particles; Nanofiber composites; Tumor cell treatment; Amino acids; Cell proliferation; Chitosan; Crosslinking; Magnetic fields; Nanofibers; Nanoparticles; Oncology; Precipitation (chemical); Hyperthermia therapy; chitosan; epichlorohydrin; iron; lactate dehydrogenase; magnetic nanoparticle; magnetite; animal cell; article; cell viability; colon carcinoma; controlled study; cytotoxicity; electric potential; electrospinning; hyperthermic therapy; in vitro study; magnetism; mouse; nonhuman; opsonization; priority journal; Animals; Cell Line, Tumor; Cell Proliferation; Chitosan; Hyperthermia, Induced; Imino Acids; Magnetics; Magnetite Nanoparticles; Materials Testing; Mice; Models, Biological; Nanocomposites; Nanofibers; Neoplasms |
顯示於: | 醫學工程學研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。