https://scholars.lib.ntu.edu.tw/handle/123456789/464437
標題: | The value of MR T2* measurements in normal and osteoarthritic knee cartilage: effects of age, sex, and location | 作者: | Tsai, P.-H. Wong, C.-C. Chan, W.P. Lu, T.-W. TUNG-WU LU |
關鍵字: | Cartilage; Diagnostic imaging; Knee; Magnetic resonance imaging (MRI); Osteoarthritis | 公開日期: | 2019 | 卷: | 29 | 期: | 8 | 起(迄)頁: | 4514-4522 | 來源出版物: | European Radiology | 摘要: | Objectives: Our aim was to investigate the role of age, sex, and location on MR T2* values of the knee cartilage in asymptomatic controls and patients with osteoarthritis (OA). Methods: A total of 100 participants, including 40 with OA and 60 asymptomatic controls, were enrolled in this study. Patients with OA were compared to age- (??41?years old) and sex-matched controls. Controls were divided by age (aged 21–40?years, 41–60, ??61). T2* values were acquired using a T2*-weighted fast gradient-echo sequence and a 1.5-T MRI scanner. T2* values of the femoral and tibial cartilages at the weight-bearing areas were obtained for comparisons. Results: The T2* values significantly increased with age and were significantly higher in the medial femoral cartilage (35.96 ± 4.06 and 31.85 ± 2.44?ms), medial tibial cartilage (30.95 ± 2.87 and 28.24 ± 1.74?ms), and lateral femoral cartilage (33.90 ± 3.15 and 31.51 ± 2.28?ms) in OA patients versus age- and sex-matched controls. Among OA patients, the T2* values for women exceed those in men in the medial femoral cartilage (37.59 ± 4.43 and 34.16 ± 2.63?ms) and medial tibial cartilage (32.17 ± 2.59 and 29.62 ± 2.53?ms; p < 0.01). Correlations were found between the Lequesne index and the T2* values for the medial femoral cartilage (r = 0.636, p < 0.001) and the medial tibial cartilage (r = 0.433, p = 0.005). Conclusion: Cartilage T2* values tend to increase with age and are useful in assessing cartilage degeneration in early OA. Key Points: ? Age, sex, and location have important effects on cartilage T2* values at the knee. ? MR T2* measurements are useful toward assessing cartilage degeneration. ? The medial femoral and tibial cartilage T2* values correlate well with disease severity. ? 2019, European Society of Radiology. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/464437 | DOI: | 10.1007/s00330-018-5826-z | SDG/關鍵字: | adult; Article; comparative study; controlled study; female; human; knee meniscus; knee osteoarthritis; major clinical study; male; middle aged; nuclear magnetic resonance imaging; priority journal; sex difference; weight bearing; age; articular cartilage; diagnostic imaging; knee; knee osteoarthritis; nuclear magnetic resonance imaging; pathology; procedures; sex factor; young adult; Adult; Age Factors; Cartilage, Articular; Female; Humans; Knee Joint; Magnetic Resonance Imaging; Male; Middle Aged; Osteoarthritis, Knee; Sex Factors; Young Adult |
顯示於: | 醫學工程學研究所 |
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