https://scholars.lib.ntu.edu.tw/handle/123456789/465541
標題: | Assessment and modeling of poly(vinyl alcohol) bioartificial pancreas in vivo | 作者: | Tai-Horng Young Chuang W.-Y Hsieh M.-Y Chen L.-W JYH-PING HSU |
關鍵字: | Bioartificial pancreas; Diabetes; Mathematical model; PVA tubular membrane chambers | 公開日期: | 2002 | 卷: | 23 | 期: | 16 | 起(迄)頁: | 3495-3501 | 來源出版物: | Biomaterials | 摘要: | Pancreatic islets surrounded by a semipermeable membrane to prevent an immune response by the host immunosystem is a potential way of treating type I diabetes mellitus. Our previous in vitro studies have demonstrated that poly(vinyl alcohol) (PVA) membranes satisfy the basic requirements for a bioartificial pancreas. This study was designed to evaluate the performance of PVA tubular membrane chambers containing islets in vivo. When the m-2 type of PVA chamber was implanted into streptozotocin-induced diabetic rats, nonfasting blood glucose levels dropped from 500±35 mg/dl to the lowest value 210±22 mg/dl. Furthermore, the performance of the bioartificial pancreas can be enhanced by the increased numbers of implanted chambers. If three m-2 chambers were implanted, nonfasting blood glucose levels in the diabetic rats decreased to 130-160 mg/dl and such a low blood glucose value was maintained for 1 month. This indicates that implanting three m-2 chambers in the diabetic rats could provide improved permeability of insulin to normalize blood glucose levels and improved survival of islets from the immune system of the recipient. For improving the design of the bioartificial pancreas, a mathematical model was developed to account for the changes in blood glucose levels of the diabetic rats. We demonstrated such a mathematical analysis was helpful to understand the characteristics of islet inside an artificial environment. ? 2002 Elsevier Science Ltd. All rights reserved. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/465541 | ISSN: | 0142-9612 | DOI: | 10.1016/S0142-9612(02)00075-3 | SDG/關鍵字: | Glucose; Immunology; Implants (surgical); Mathematical models; Polymeric membranes; Bioartificial pancreas; Biomaterials; polyvinyl alcohol; biomaterial; insulin; animal model; article; bioartificial organ; controlled study; diabetes mellitus; diet restriction; evaluation; glucose blood level; implantation; in vivo study; mathematical analysis; membrane; membrane permeability; model; nonhuman; pancreas; pancreas islet; performance; priority journal; rat; animal; artificial pancreas; biological model; blood; experimental diabetes mellitus; metabolism; pancreas islet; secretion; Wistar rat; Animal; Biocompatible Materials; Blood Glucose; Diabetes Mellitus, Experimental; Insulin; Islets of Langerhans; Models, Biological; Pancreas, Artificial; Polyvinyl Alcohol; Rats; Rats, Wistar; Support, Non-U.S. Gov't; Animals; Blood Glucose; Insulin; Models, Biological; Rats; Rats, Wistar; Potato virus A |
顯示於: | 醫學工程學研究所 |
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