https://scholars.lib.ntu.edu.tw/handle/123456789/465712
標題: | Biodegradable and Multifunctional Microspheres for Treatment of Hepatoma through Transarterial Embolization | 作者: | Chiang P.-F. Peng C.-L. Shih Y.-H. Cho Y.-H. Yu C.-S. Kuo Y.-M. MING-JIUM SHIEH Luo T.-Y. |
關鍵字: | 188Re; doxorubicin; hepatocellular carcinoma; microsphere; transcatheter arterial embolization | 公開日期: | 2018 | 出版社: | American Chemical Society | 卷: | 4 | 期: | 9 | 起(迄)頁: | 3425-3433 | 來源出版物: | ACS Biomaterials Science and Engineering | 摘要: | To improve the effectiveness of cancer treatment, this study aimed to develop biodegradable microspheres and to combine chemotherapy and radiotherapy via transcatheter arterial embolization/chemoembolization (TAE/TACE) with local radiation therapy for the slow release of chemotherapeutic agents. Microparticles were prepared by double emulsification using a biodegradable and biocompatible polymer Poly(D,l-lactide-co-glycolide) (PLGA). Since the microspheres contain a water-soluble Poly(vinylsulfonic acid) (PVSA) solution, the functional groups of this polymer dissociate into -SO3 - in water. The positively charged doxorubicin can be loaded into beads, ensuring slow release. After 188Retin colloids were added into the microspheres, TACE was performed in a rat hepatocellular carcinoma model. Single photon emission computed tomography/computed tomography imaging and biodistribution analyses showed that the microspheres were still in the liver after 72 h. During 4 weeks of observation, ultrasound images showed that the Re/DOX@MS treatment had the most significant inhibitory effect on tumor growth. Biodegradable PLGA microspheres have the advantage of enabling local embolization therapy with reduced adverse effects. In the future, microspheres could serve as a drug delivery system for cancer treatment by combining therapeutic radionuclides and chemotherapeutic drugs, thereby improving treatment effects for hepatocellular carcinoma. Copyright ? 2018 American Chemical Society. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85053181465&doi=10.1021%2facsbiomaterials.8b00635&partnerID=40&md5=2af4e1a627f062a6b297cfbdfcd4017a https://scholars.lib.ntu.edu.tw/handle/123456789/465712 |
ISSN: | 2373-9878 | DOI: | 10.1021/acsbiomaterials.8b00635 | SDG/關鍵字: | Biocompatibility; Biodegradable polymers; Chemotherapy; Controlled drug delivery; Diseases; Emulsification; Organic polymers; Particle beams; Radiotherapy; Single photon emission computed tomography; Targeted drug delivery; Tomography; Biodegradable microspheres; Doxorubicin; Hepatocellular carcinoma; Poly(D ,L-lactide-co-glycolide); Therapeutic radionuclides; Transarterial embolization; Transcatheter arterial embolization; ^188Re; Microspheres; doxorubicin; microsphere; polyglactin; animal cell; animal experiment; animal model; Article; biodegradability; cancer inhibition; cell viability; chemoembolization; controlled study; drug cytotoxicity; drug degradation; drug purity; drug release; Fischer 344 rat; hydrophobicity; liver cell carcinoma; male; microtechnology; nonhuman; priority journal; radioactivity; rat; single photon emission computed tomography-computed tomography |
顯示於: | 醫學工程學研究所 |
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