https://scholars.lib.ntu.edu.tw/handle/123456789/465737
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.author | Lee S.-Y. | en_US |
dc.contributor.author | MING-JIUM SHIEH | en_US |
dc.creator | Lee S.-Y.;Ming-Jium Shieh | - |
dc.date.accessioned | 2020-02-27T06:39:27Z | - |
dc.date.available | 2020-02-27T06:39:27Z | - |
dc.date.issued | 2016 | - |
dc.identifier.uri | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84988946218&partnerID=40&md5=47f2f1e89099f9f07aa7b0dc766ec050 | - |
dc.identifier.uri | https://scholars.lib.ntu.edu.tw/handle/123456789/465737 | - |
dc.description.abstract | In the present study, we established a multifunctional gold nanoshell (GNS) that utilizing positively charged PDMA-b-PCL micelles as a template. By growing the gold layer on the surface of micelles, this newly synthesized GNS with micellar core enable the delivery of hydrophobic chemotherapeutics. The synthesized SN-38@pGNS had a spherical morphology and a narrow size distribution. With the exposure to NIR laser irradiation, SN-38@pGNS exhibited an excellent photothermal conversion efficiency. Moreover, the combination of chemotherapy and photothermal therapy resulted in a significant anticancer effect in the in vitro study. These results suggested the gold nanoshells with micellar core can serve as not only a photothermal mediator but also a delivery system for hydrophobic drugs. Therefore, the synthesized gold nanoshells with micellar core can be applied as a potential multifunctional therapeutics for cancer therapy in the future. | - |
dc.publisher | TechConnect | - |
dc.relation.ispartof | Advanced Materials - TechConnect Briefs 2016 | - |
dc.subject | Chemotherapy; Gold nanoshell; Micelles; Photothermal therapy; SN-38 | - |
dc.subject.classification | [SDGs]SDG3 | - |
dc.subject.other | Chemotherapy; Diseases; Gold; Hydrophobicity; Micelles; Nanostructured materials; Nanostructures; Anticancer effects; Cancer photothermal therapies; Gold nanoshells; Narrow size distributions; NIR laser irradiation; Photothermal conversion efficiencies; Photothermal therapy; Spherical morphologies; Nanoshells | - |
dc.title | Gold nanoshells with micellar core for the delivery of hydrophobic chemotherapeutic and cancer photothermal therapy | en_US |
dc.type | conference paper | en |
dc.identifier.scopus | 2-s2.0-84988946218 | - |
dc.relation.pages | 161-164 | - |
dc.relation.journalvolume | 3 | - |
item.openairetype | conference paper | - |
item.openairecristype | http://purl.org/coar/resource_type/c_5794 | - |
item.fulltext | no fulltext | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
crisitem.author.dept | Biomedical Engineering | - |
crisitem.author.dept | Oncology-NTUH | - |
crisitem.author.dept | School of Medicine | - |
crisitem.author.orcid | 0000-0003-2921-4443 | - |
crisitem.author.parentorg | College of Medicine | - |
crisitem.author.parentorg | College of Engineering | - |
crisitem.author.parentorg | National Taiwan University Hospital | - |
crisitem.author.parentorg | College of Medicine | - |
顯示於: | 醫學工程學研究所 |
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