https://scholars.lib.ntu.edu.tw/handle/123456789/465745
標題: | Enhanced efficacy of chemotherapeutic drugs against colorectal cancer using ligand-decorated self-breakable agents | 作者: | Tsai M.-H. Peng C.-L. Yao C.-J. MING-JIUM SHIEH |
公開日期: | 2015 | 出版社: | Royal Society of Chemistry | 卷: | 5 | 期: | 112 | 起(迄)頁: | 92361-92370 | 來源出版物: | RSC Advances | 摘要: | Several types of nano-sized anti-cancer agents that could increase the accumulation of drugs in tumor sites have been created and developed to enhance the efficacy of chemotherapeutic drugs in colon cancer treatment. In addition, to achieve the optimal cancer chemotherapeutic efficacy, nano-sized agents with specific functions were designed to efficiently kill cancer cells. The ideal nano-sized agent must be able to successfully release the drug and result in an increased cellular uptake of the chemotherapeutic drug. Our research team focused on two important functions, i.e. drug release and targeting functions, thus targeting functional micelles that were designed to possess disulfide bonds and entrapped much of the chemotherapeutic drug, 7-ethyl-10-hydroxy-camptothecin (SN38), which was created as a powerful candidate for an ideal anti-cancer drug for colon cancer treatment. In particular, self-breakable SN38-loaded micelles (SN/38 micelles), non-breakable SN38-loaded micelles (NB/38 micelles) and folate-decorated self-breakable SN38-loaded micelles (FSB/38 micelles) were prepared and tested on the designed agents. The results showed that the folate-decorated functional micelles with disulfide bonds could be an effective chemotherapeutic agent for colon cancer treatment. ? The Royal Society of Chemistry 2015. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84946606966&doi=10.1039%2fc5ra16175d&partnerID=40&md5=7aa88e6d2c34d6749daefa144cbd3078 https://scholars.lib.ntu.edu.tw/handle/123456789/465745 |
ISSN: | 2046-2069 | DOI: | 10.1039/c5ra16175d | SDG/關鍵字: | Covalent bonds; Micelles; Anti-cancer agents; Anticancer drug; Cellular uptake; Chemotherapeutic agents; Chemotherapeutic drugs; Colorectal cancer; Disulfide bonds; Research teams; Diseases |
顯示於: | 醫學工程學研究所 |
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