https://scholars.lib.ntu.edu.tw/handle/123456789/465759
標題: | Development of in situ forming thermosensitive hydrogel for radiotherapy combined with chemotherapy in a mouse model of hepatocellular carcinoma | 作者: | Peng C.-L. Shih Y.-H. Liang K.-S. Chiang P.-F. Yeh C.-H. Tang I.-C. Yao C.-J. Lee S.-Y. Luo T.-Y. MING-JIUM SHIEH |
關鍵字: | chemotherapy; drug delivery; hepatocellular carcinoma; radiotherapy; thermally responsive material | 公開日期: | 2013 | 卷: | 10 | 期: | 5 | 起(迄)頁: | 1854-1864 | 來源出版物: | Molecular Pharmaceutics | 摘要: | This study evaluated a system for local cancer radiotherapy combined with chemotherapy. The delivery system is a thermosensitive hydrogel containing a therapeutic radionuclide (188Re-Tin colloid) and a chemotherapeutic drug (liposomal doxorubicin). The thermosensitive PCL-PEG-PCL copolymer was designed to spontaneously undergo a sol-gel phase transition in response to temperature, remaining liquid at room temperature and rapidly forming a gel at body temperature. A scanning electron microscope was used to observe the microstructure of the fully loaded hydrogel. Release of radionuclide and doxorubicin from the hydrogel was slow, and the system tended to remain stable for at least 10 days. After the intratumoral administration of Lipo-Dox/ 188Re-Tin hydrogel in mice with hepatocellular carcinoma (HCC), its retention by the tumor, spatiotemporal distribution, and therapeutic effect were evaluated. The residence time in the tumor was significantly longer for 188Re-Tin loaded hydrogel than for Na 188Re perrhenate (Na 188ReO4). The hydrogel after thermal transition kept the radionuclide inside the tumor, whereas free 188Re perrhenate ( 188ReO4) diffused quickly from the tumor. The tumor growth was more profoundly inhibited by treatment with Lipo-Dox/188Re-Tin hydrogel (with up to 80% regression of well-established tumors on day 32) than treatment with either 188Re-Tin hydrogel or Lipo-Dox hydrogel. Therefore, this injectable and biodegradable hydrogel may offer the advantage of focusing radiotherapy and chemotherapy locally to maximize their effects on hepatocellular carcinoma. ? 2013 American Chemical Society. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84877309937&doi=10.1021%2fmp3006424&partnerID=40&md5=5a5ff336ee88e742a6340a184e38027b https://scholars.lib.ntu.edu.tw/handle/123456789/465759 |
ISSN: | 1543-8384 | DOI: | 10.1021/mp3006424 | SDG/關鍵字: | copolymer; diagnostic agent; doxorubicin; lipo dox; perrhenate re 188; poly(epsilon caprolactone) poly(ethylene glycol) poly(epsilon caprolactone); radioisotope; radiopharmaceutical agent; tin colloid re 188; unclassified drug; (188)Rhenium tin-colloid; colloid; doxorubicin; hydrogel; liposome; macrogol derivative; poly(epsilon-caprolactone)-b-poly(ethyleneglycol)-b-poly(epsilon-caprolactone); polyester; radiopharmaceutical agent; rhenium; tin; animal experiment; animal model; animal tissue; article; body temperature; cancer chemotherapy; cancer inhibition; cancer model; cancer radiotherapy; chemoradiotherapy; controlled study; drug delivery system; drug distribution; drug efficacy; drug retention; evaluation; heat sensitivity; hydrogel; liver cell carcinoma; male; mean residence time; mouse; nonhuman; phase transition; priority journal; room temperature; scanning electron microscopy; animal; Bagg albino mouse; chemistry; chemoradiotherapy; colloid; hydrogel; Liver Neoplasms, Experimental; multimodality cancer therapy; pathology; procedures; temperature; tumor cell line; Animals; Cell Line, Tumor; Chemoradiotherapy; Colloids; Combined Modality Therapy; Doxorubicin; Drug Delivery Systems; Hydrogels; Liposomes; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred BALB C; Polyesters; Polyethylene Glycols; Radiopharmaceuticals; Rhenium; Temperature; Tin |
顯示於: | 醫學工程學研究所 |
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